Sutherland C, et al. (1993) Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2. Eur J Biochem 217, 715-22 7901013

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S19-p - TH (human) ▲
Modsite: KGFRRAVsELDAKQA SwissProt Entrez-Gene Orthologous residues TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE MAPKAPK2 (human) KINASE CAMK2A (rat)

S62-p - TH (human) ▲
Modsite: SYTPTPRsPRFIGRR SwissProt Entrez-Gene Orthologous residues TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE ERK1 (human) Downstream Regulation Effect of modification (function):  enzymatic activity, induced

S71-p - TH (human) ▲

Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene Orthologous residues TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE CAMK2A (rat) KINASE PKACA (cow) KINASE MAPKAPK2 (human) KINASE RSK2 (human) Downstream Regulation Effect of modification (function):  enzymatic activity, induced

S19-p - TH iso2 (human) ▲
Modsite: KGFRRAVsELDAKQA SwissProt Entrez-Gene Orthologous residues TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE MAPKAPK2 (human) KINASE CAMK2A (rat)

S58-p - TH iso2 (human) ▲
Modsite: SYTPTPRsPRFIGRR SwissProt Entrez-Gene Orthologous residues TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE ERK1 (human) Downstream Regulation Effect of modification (function):  enzymatic activity, induced

S67-p - TH iso2 (human) ▲

Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene Orthologous residues TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE RSK2 (human) KINASE MAPKAPK2 (human) KINASE CAMK2A (rat) KINASE PKACA (cow) Downstream Regulation Effect of modification (function):  enzymatic activity, induced

S19-p - TH iso3 (human) ▲
Modsite: KGFRRAVsELDAKQA SwissProt Entrez-Gene Orthologous residues TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE MAPKAPK2 (human) KINASE CAMK2A (rat)

S31-p - TH iso3 (human) ▲
Modsite: KQAEAIMsPRFIGRR SwissProt Entrez-Gene Orthologous residues TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE ERK1 (human) Downstream Regulation Effect of modification (function):  enzymatic activity, induced

S40-p - TH iso3 (human) ▲

Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene Orthologous residues TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE MAPKAPK2 (human) KINASE RSK2 (human) KINASE CAMK2A (rat) KINASE PKACA (cow) Downstream Regulation Effect of modification (function):  enzymatic activity, induced

S19-p - TH iso4 (human) ▲
Modsite: KGFRRAVsELDAKQA SwissProt Entrez-Gene Orthologous residues TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE MAPKAPK2 (human) KINASE CAMK2A (rat)

S35-p - TH iso4 (human) ▲
Modsite: AIMVRGQsPRFIGRR SwissProt Entrez-Gene Orthologous residues TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE ERK1 (human) Downstream Regulation Effect of modification (function):  enzymatic activity, induced

S44-p - TH iso4 (human) ▲

Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene Orthologous residues TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE RSK2 (human) KINASE PKACA (cow) KINASE MAPKAPK2 (human) KINASE CAMK2A (rat) Downstream Regulation Effect of modification (function):  enzymatic activity, induced