Curated Information
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Home > Curated Information Page > PubMed Id: 7901013
Sutherland C, et al. (1993) Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2. Eur J Biochem 217, 715-22 7901013
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S19-p - TH (human)
Modsite: KGFRRAVsELDAKQA SwissProt Entrez-Gene
Orthologous residues
TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CAMK2A (rat)
KINASE MAPKAPK2 (human)

S62-p - TH (human)
Modsite: SYTPTPRsPRFIGRR SwissProt Entrez-Gene
Orthologous residues
TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK1 (human)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

S71-p - TH (human)
Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene
Orthologous residues
TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE MAPKAPK2 (human)
KINASE PKACA (cow)
KINASE CAMK2A (rat)
KINASE RSK2 (human)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

S19-p - TH iso2 (human)
Modsite: KGFRRAVsELDAKQA SwissProt Entrez-Gene
Orthologous residues
TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE MAPKAPK2 (human)
KINASE CAMK2A (rat)

S58-p - TH iso2 (human)
Modsite: SYTPTPRsPRFIGRR SwissProt Entrez-Gene
Orthologous residues
TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK1 (human)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

S67-p - TH iso2 (human)
Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene
Orthologous residues
TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE RSK2 (human)
KINASE MAPKAPK2 (human)
KINASE PKACA (cow)
KINASE CAMK2A (rat)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

S19-p - TH iso3 (human)
Modsite: KGFRRAVsELDAKQA SwissProt Entrez-Gene
Orthologous residues
TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CAMK2A (rat)
KINASE MAPKAPK2 (human)

S31-p - TH iso3 (human)
Modsite: KQAEAIMsPRFIGRR SwissProt Entrez-Gene
Orthologous residues
TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK1 (human)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

S40-p - TH iso3 (human)
Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene
Orthologous residues
TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CAMK2A (rat)
KINASE PKACA (cow)
KINASE RSK2 (human)
KINASE MAPKAPK2 (human)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

S19-p - TH iso4 (human)
Modsite: KGFRRAVsELDAKQA SwissProt Entrez-Gene
Orthologous residues
TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE MAPKAPK2 (human)
KINASE CAMK2A (rat)

S35-p - TH iso4 (human)
Modsite: AIMVRGQsPRFIGRR SwissProt Entrez-Gene
Orthologous residues
TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK1 (human)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

S44-p - TH iso4 (human)
Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene
Orthologous residues
TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CAMK2A (rat)
KINASE PKACA (cow)
KINASE RSK2 (human)
KINASE MAPKAPK2 (human)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced