Curated Information
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Home > Curated Information Page > PubMed Id: 16407161
Kawasaki BT, Liao Y, Birnbaumer L (2006) Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channels. Proc Natl Acad Sci U S A 103, 335-40 16407161
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y37-p - TRPC3 (human)
Modsite: RFLDAAEyGNIPVVR SwissProt Entrez-Gene
Orthologous residues
TRPC3 (human): Y37‑p, TRPC3 iso2 (human): Y122‑p, TRPC3 iso3 (human): Y49‑p, TRPC3 (mouse): Y37‑p, TRPC3 iso4 (mouse): Y111‑p, TRPC3 (rat): Y37‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y136-p - TRPC3 (human)
Modsite: ELQDDDFyAyDEDGT SwissProt Entrez-Gene
Orthologous residues
TRPC3 (human): Y136‑p, TRPC3 iso2 (human): Y221‑p, TRPC3 iso3 (human): Y148‑p, TRPC3 (mouse): Y136‑p, TRPC3 iso4 (mouse): Y210‑p, TRPC3 (rat): Y136‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y138-p - TRPC3 (human)
Modsite: QDDDFyAyDEDGTRF SwissProt Entrez-Gene
Orthologous residues
TRPC3 (human): Y138‑p, TRPC3 iso2 (human): Y223‑p, TRPC3 iso3 (human): Y150‑p, TRPC3 (mouse): Y138‑p, TRPC3 iso4 (mouse): Y212‑p, TRPC3 (rat): Y138‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y214-p - TRPC3 (human)
Modsite: KGLASPAyLSLSSED SwissProt Entrez-Gene
Orthologous residues
TRPC3 (human): Y214‑p, TRPC3 iso2 (human): Y299‑p, TRPC3 iso3 (human): Y226‑p, TRPC3 (mouse): Y214‑p, TRPC3 iso4 (mouse): Y288‑p, TRPC3 (rat): Y214‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)
Downstream Regulation
Effect of modification (function):  activity, induced