Curated Information
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Home > Curated Information Page > PubMed Id: 29935031
Wang Y, et al. (2018) PKG II inhibits PDGF-BB triggered biological activities by phosphorylating PDGFRβ in gastric cancer cells. Cell Biol Int 29935031
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S712-p - PDGFRB (human)
Modsite: sDkRRPPsAELysNA SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): S712‑p, PDGFRB (mouse): S711‑p, PDGFRB (rat): S711‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKG2 (human) co-immunoprecipitation, transfection of wild-type enzyme, pharmacological activator of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
8pCPT-cGMP increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, inhibited, phosphorylation
Effect of modification (process):  signaling pathway regulation
Comments:  regulates MEK/ERK and PI3K/AKT mediated pathways, inhibits phosphorylation of Y751