Curated Information
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Home > Curated Information Page > PubMed Id: 16361709
Markou T, Yong CS, Sugden PH, Clerk A (2006) Regulation of protein kinase C delta by phorbol ester, endothelin-1, and platelet-derived growth factor in cardiac myocytes. J Biol Chem 281, 8321-31 16361709
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T505-p - PKCD (rat)
Modsite: FGENRAstFCGTPDy SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T507‑p, PKCD iso2 (human): T538‑p, PKCD (mouse): T505‑p, PKCD iso2 (mouse): T531‑p, PKCD (rat): T505‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
phorbol_ester increase
GF109203X phorbol_ester inhibit treatment-induced increase
LY294002 phorbol_ester no effect upon treatment-induced increase
PP2 phorbol_ester no effect upon treatment-induced increase
endothelin increase
GF109203X endothelin inhibit treatment-induced increase
LY294002 endothelin no effect upon treatment-induced increase
PP2 endothelin no effect upon treatment-induced increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

S643-p - PKCD (rat)
Modsite: LNEKPQLsFsDKNLI SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S645‑p, PKCD iso2 (human): S676‑p, PKCD (mouse): S643‑p, PKCD iso2 (mouse): S669‑p, PKCD (rat): S643‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
endothelin increase
GF109203X endothelin inhibit treatment-induced increase
LY294002 endothelin inhibit treatment-induced increase
PP2 endothelin inhibit treatment-induced increase
phorbol_ester increase
GF109203X phorbol_ester inhibit treatment-induced increase
LY294002 phorbol_ester inhibit treatment-induced increase
PP2 phorbol_ester inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced