Chong C, Tan L, Lim L, Manser E (2001) The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity. J Biol Chem 276, 17347-53 11278486

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S144-p - PAK1 (rat) ▲

Modsite: SNSQKYMsFTDKsAE SwissProt Entrez-Gene Orthologous residues PAK1 (human): S144‑p, PAK1 (mouse): S144‑p, PAK1 (rat): S144‑p Characterization Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site Relevant cell lines - cell types - tissues:  COS (fibroblast), HeLa (cervical) Cellular systems studied:  cell lines Species studied:  green monkey, human Downstream Regulation Effect of modification (function):  enzymatic activity, induced

S149-p - PAK1 (rat) ▲

Modsite: YMsFTDKsAEDYNSS SwissProt Entrez-Gene Orthologous residues PAK1 (human): S149‑p, PAK1 (mouse): S149‑p, PAK1 (rat): S149‑p Characterization Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site Relevant cell lines - cell types - tissues:  COS (fibroblast), HeLa (cervical) Cellular systems studied:  cell lines Species studied:  green monkey, human Downstream Regulation Effect of modification (function):  enzymatic activity, induced

T422-p - PAK1 (rat) ▲

Modsite: PEQSKRstMVGTPYW SwissProt Entrez-Gene Orthologous residues PAK1 (human): T423‑p, PAK1 (mouse): T423‑p, PAK1 (rat): T422‑p Characterization Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site Relevant cell lines - cell types - tissues:  COS (fibroblast), HeLa (cervical) Cellular systems studied:  cell lines Species studied:  green monkey, human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PAK1 (rat) Downstream Regulation Effect of modification (function):  enzymatic activity, induced

S50-p - PAK3 (rat) ▲
Modsite: NKKARLRsIFPGGGD SwissProt Entrez-Gene Orthologous residues PAK3 (human): S50‑p, PAK3 iso3 (human): S50‑p, PAK3 (mouse): S50‑p, PAK3 (rat): S50‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE PAK3 (rat)

S139-p - PAK3 (rat) ▲

Modsite: VNNQKYMsFTSGDKS SwissProt Entrez-Gene Orthologous residues PAK3 (human): S154‑p, PAK3 iso3 (human): S175‑p, PAK3 (mouse): S154‑p, PAK3 (rat): S139‑p Characterization Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site Relevant cell lines - cell types - tissues:  COS (fibroblast), HeLa (cervical) Cellular systems studied:  cell lines Species studied:  green monkey, human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PAK3 (rat) Downstream Regulation Effect of modification (function):  enzymatic activity, induced

T421-p - PAK3 (rat) ▲

Modsite: PEQSKRstMVGTPYW SwissProt Entrez-Gene Orthologous residues PAK3 (human): T436‑p, PAK3 iso3 (human): T457‑p, PAK3 (mouse): T436‑p, PAK3 (rat): T421‑p Characterization Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site Relevant cell lines - cell types - tissues:  COS (fibroblast), HeLa (cervical) Cellular systems studied:  cell lines Species studied:  green monkey, human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PAK3 (rat) Downstream Regulation Effect of modification (function):  enzymatic activity, induced