Ward DG, et al. (2004) NMR and mutagenesis studies on the phosphorylation region of human cardiac troponin I. Biochemistry 43, 5772-81 15134451

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S23-p - TNNI3 (human) ▲

Modsite: PAPIRRRssNyRAyA SwissProt Entrez-Gene Orthologous residues TNNI3 (human): S23‑p, TNNI3 (mouse): S23‑p, TNNI3 (rat): S23‑p, TNNI3 (rabbit): S22‑p, TNNI3 (dog): S23‑p, TNNI3 (cow): S24‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCA (human) Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays TNNC1 (human) Disrupts molecular association, regulation in vitro, NMR spectroscopy

S24-p - TNNI3 (human) ▲

Modsite: APIRRRssNyRAyAt SwissProt Entrez-Gene Orthologous residues TNNI3 (human): S24‑p, TNNI3 (mouse): S24‑p, TNNI3 (rat): S24‑p, TNNI3 (rabbit): S23‑p, TNNI3 (dog): S24‑p, TNNI3 (cow): S25‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCA (human) Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays TNNC1 (human) Disrupts molecular association, regulation in vitro, NMR spectroscopy

S42-p - TNNI3 (human) ▲

Modsite: AKKKskIsAsRKLQL SwissProt Entrez-Gene Orthologous residues TNNI3 (human): S42‑p, TNNI3 (mouse): S43‑p, TNNI3 (rat): S43‑p, TNNI3 (rabbit): S42‑p, TNNI3 (dog): S43‑p, TNNI3 (cow): S44‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCA (human) Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays TNNC1 (human) Disrupts molecular association, regulation in vitro, NMR spectroscopy

S44-p - TNNI3 (human) ▲

Modsite: KKskIsAsRKLQLKt SwissProt Entrez-Gene Orthologous residues TNNI3 (human): S44‑p, TNNI3 (mouse): S45‑p, TNNI3 (rat): S45‑p, TNNI3 (rabbit): S44‑p, TNNI3 (dog): S45‑p, TNNI3 (cow): S46‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCA (human) Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays TNNC1 (human) Disrupts molecular association, regulation in vitro, NMR spectroscopy