Curated Information
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Home > Curated Information Page > PubMed Id: 15662016
Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH (2005) T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 307, 430-3 15662016
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y525-p - TBX21 (mouse)
Modsite: KETEGQFyNYFPN__ SwissProt Entrez-Gene
Orthologous residues
TBX21 (human): Y530‑p, TBX21 (mouse): Y525‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), lymphocyte
Cellular systems studied:  primary cultured cells
Species studied:  mouse
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ITK (mouse) genetic knockout/knockin of upstream enzyme, phospho-antibody, co-immunoprecipitation, transfection of wild-type enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase
anti-CD28 increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  transcription, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
GATA3 (mouse) Induces molecular association, regulation transcription, altered co-immunoprecipitation