Curated Information
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Home > Curated Information Page > PubMed Id: 16256741
Li J, et al. (2005) Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration. Dev Cell 9, 663-73 16256741
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S554-p - CENTB1 (human)
Modsite: sIRPRPGsLRSkPEP SwissProt Entrez-Gene
Orthologous residues
CENTB1 (human): S554‑p, CENTB1 (mouse): I554‑p, CENTB1 (rat): I554‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mass spectrometry, mutation of modification site
Relevant cell lines - cell types - tissues:  HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) antisense inhibition of upstream enzyme
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell motility, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ITGB1 (human) Induces intracellular localization co-immunoprecipitation