Curated Information
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Home > Curated Information Page > PubMed Id: 19275932
Srinivasan D, Kaetzel DM, Plattner R (2009) Reciprocal regulation of Abl and receptor tyrosine kinases. Cell Signal 21, 1143-50 19275932
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y226-p - Abl (human)
Modsite: KRNKPtVyGVsPNyD SwissProt Entrez-Gene
Orthologous residues
Abl (human): Y226‑p, Abl iso2 (human): Y245‑p, Abl (mouse): Y226‑p, Abl iso4 (mouse): Y245‑p, Abl (rat): Y226‑p, Abl iso2 (rat): Y245‑p

Y393-p - Abl (human)
Modsite: RLMtGDtytAHAGAk SwissProt Entrez-Gene
Orthologous residues
Abl (human): Y393‑p, Abl iso2 (human): Y412‑p, Abl (mouse): Y393‑p, Abl iso4 (mouse): Y412‑p, Abl (rat): Y393‑p, Abl iso2 (rat): Y412‑p

Y139-p - Arg (human)
Modsite: EKLRVLGyNQNGEWS SwissProt Entrez-Gene
Orthologous residues
Arg (human): Y139‑p, Arg iso2 (human): Y103‑p, Arg iso4 (human): Y104‑p, Arg iso6 (human): Y118‑p, Arg iso10 (human): Y124‑p, Arg (mouse): Y139‑p, Arg (rat): Y137‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PDGFRB (human)

Y161-p - Arg (human)
Modsite: QGWVPsNyItPVNSL SwissProt Entrez-Gene
Orthologous residues
Arg (human): Y161‑p, Arg iso2 (human): Y125‑p, Arg iso4 (human): Y126‑p, Arg iso6 (human): Y140‑p, Arg iso10 (human): Y146‑p, Arg (mouse): Y161‑p, Arg (rat): Y159‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PDGFRB (human)

Y272-p - Arg (human)
Modsite: KCNKPTVyGVsPIHD SwissProt Entrez-Gene
Orthologous residues
Arg (human): Y272‑p, Arg iso2 (human): Y236‑p, Arg iso4 (human): Y237‑p, Arg iso6 (human): Y251‑p, Arg iso10 (human): Y257‑p, Arg (mouse): Y272‑p, Arg (rat): Y270‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PDGFRB (human)

Y686-p - PDGFRB (human)
Modsite: IITEyCRyGDLVDyL SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y686‑p, PDGFRB (mouse): Y685‑p, PDGFRB (rat): Y685‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Abl (human) activation of upstream enzyme, transfection of wild-type enzyme
KINASE Arg (human) activation of upstream enzyme, transfection of wild-type enzyme
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Effect of modification (process):  cell motility, altered
Comments:  in vitro

Y934-p - PDGFRB (human)
Modsite: AHAsDEIyEIMQKCW SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y934‑p, PDGFRB (mouse): Y933‑p, PDGFRB (rat): Y933‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Abl (human) activation of upstream enzyme, transfection of wild-type enzyme
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Effect of modification (process):  cell motility, altered
Comments:  in vitro

Y970-p - PDGFRB (human)
Modsite: GEGYKKKyQQVDEEF SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y970‑p, PDGFRB (mouse): Y969‑p, PDGFRB (rat): Y969‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Abl (human) activation of upstream enzyme, transfection of wild-type enzyme
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Effect of modification (process):  cell motility, altered
Comments:  in vitro