Curated Information
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Home > Curated Information Page > PubMed Id: 1314164
Kashishian A, Kazlauskas A, Cooper JA (1992) Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo. EMBO J 11, 1373-82 1314164
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y716-p - PDGFRB (human)
Modsite: RPPsAELysNALPVG SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y716‑p, PDGFRB (mouse): Y715‑p, PDGFRB (rat): Y715‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase

Y740-p - PDGFRB (human)
Modsite: TGESDGGyMDMSKDE SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y740‑p, PDGFRB (mouse): Y739‑p, PDGFRB (rat): Y739‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3R1 (human) Induces functional assay, in vitro
Comments:  PIK3R1 kinase activity assay

Y751-p - PDGFRB (human)
Modsite: SKDESVDyVPMLDMK SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y751‑p, PDGFRB (mouse): Y750‑p, PDGFRB (rat): Y750‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3R1 (human) Induces functional assay, in vitro
Comments:  PIK3R1 kinase activity assay

Y763-p - PDGFRB (human)
Modsite: DMKGDVKyADIESSN SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y763‑p, PDGFRB (mouse): Y762‑p, PDGFRB (rat): Y762‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase

Y771-p - PDGFRB (human)
Modsite: ADIESSNyMAPyDNy SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y771‑p, PDGFRB (mouse): Y770‑p, PDGFRB (rat): Y770‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RASA1 (human) Induces co-immunoprecipitation

Y775-p - PDGFRB (human)
Modsite: SSNyMAPyDNyVPSA SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y775‑p, PDGFRB (mouse): Y774‑p, PDGFRB (rat): Y774‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase

Y778-p - PDGFRB (human)
Modsite: yMAPyDNyVPSAPER SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y778‑p, PDGFRB (mouse): Y777‑p, PDGFRB (rat): Y777‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase

Y857-p - PDGFRB (human)
Modsite: DIMRDSNyISKGSTF SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y857‑p, PDGFRB (mouse): Y856‑p, PDGFRB (rat): Y856‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase