Uematsu K, et al. (2005) Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP-32-dependent and independent pathways. J Neurochem 95, 1642-52 16300646

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S94-p - Spinophilin (mouse) ▲

Modsite: SDRGVRLsLPRAssL SwissProt Entrez-Gene Orthologous residues Spinophilin (human): S94‑p, Spinophilin (mouse): S94‑p, Spinophilin (rat): S94‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  'brain, neostriatum' Cellular systems studied:  tissue Species studied:  mouse Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes PHOSPHATASE PPP1CA (human) pharmacological inhibitor of upstream enzyme PHOSPHATASE PPP2CA (human) pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes SKF81297 increase quinpirole SKF81297 no effect upon treatment-induced increase NMDA SKF81297 inhibit treatment-induced increase CGS_21680 increase quinpirole CGS_21680 inhibit treatment-induced increase NMDA CGS_21680 inhibit treatment-induced increase quinpirole decrease okadaic_acid increase NMDA decrease okadaic_acid NMDA inhibit treatment-induced decrease ciclosporin NMDA no effect upon treatment-induced decrease AMPA decrease