Curated Information
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Home > Curated Information Page > PubMed Id: 16275766
Hwang ES, Hong JH, Glimcher LH (2005) IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. J Exp Med 202, 1289-300 16275766
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S508-p - TBX21 (mouse)
Modsite: PsSGDSSsPAGAPsP SwissProt Entrez-Gene
Orthologous residues
TBX21 (human): S513‑p, TBX21 (mouse): S508‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  AE7, HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1A (human)
KINASE GSK3A (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
NFkB-p65 (human) Induces activity, inhibited co-immunoprecipitation
Comments:  DNA binding activity of NFkB-p65 is reduced in the presence of T-bet