Curated Information
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Home > Curated Information Page > PubMed Id: 14680475
Kuma Y, Campbell DG, Cuenda A (2004) Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta. Biochem J 379, 133-9 14680475
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S645-p - GYS1 (human)
Modsite: RPAsVPPsPsLsRHs SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S645‑p, GYS1 iso2 (human): S581‑p, GYS1 (mouse): S645‑p, GYS1 (rat): S645‑p, GYS1 (rabbit): S645‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
KINASE P38B (human)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
osmotic_stress increase
SB203580 osmotic_stress inhibit treatment-induced increase

S653-p - GYS1 (human)
Modsite: PsLsRHssPHQsEDE SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S653‑p, GYS1 iso2 (human): S589‑p, GYS1 (mouse): S653‑p, GYS1 (rat): S653‑p, GYS1 (rabbit): S653‑p

T721-p - GYS1 (human)
Modsite: AtsssLStPsEPLsP SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): T721‑p, GYS1 iso2 (human): T657‑p, GYS1 (mouse): T722‑p, GYS1 (rat): T722‑p, GYS1 (rabbit): T719‑p

S727-p - GYS1 (human)
Modsite: StPsEPLsPtssLGE SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S727‑p, GYS1 iso2 (human): S663‑p, GYS1 (mouse): S728‑p, GYS1 (rat): S728‑p, GYS1 (rabbit): S725‑p