Curated Information
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Home > Curated Information Page > PubMed Id: 15688006
Chan EH, et al. (2005) The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene 24, 2076-86 15688006
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S613-p - LATS1 (human)
Modsite: EKKQITtsPItVRKN SwissProt Entrez-Gene
Orthologous residues
LATS1 (human): S613‑p, LATS1 (mouse): S612‑p, LATS1 (rat): S613‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S633-p - LATS1 (human)
Modsite: RRESRIQsYsPQAFK SwissProt Entrez-Gene
Orthologous residues
LATS1 (human): S633‑p, LATS1 (mouse): S632‑p, LATS1 (rat): S633‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S674-p - LATS1 (human)
Modsite: EMMRVGLsQDAQDQM SwissProt Entrez-Gene
Orthologous residues
LATS1 (human): S674‑p, LATS1 (mouse): S673‑p, LATS1 (rat): S674‑p

S872-p - LATS1 (human)
Modsite: GDHPRQDsMDFSNEW SwissProt Entrez-Gene
Orthologous residues
LATS1 (human): S872‑p, LATS1 (mouse): S871‑p, LATS1 (rat): S872‑p

S909-p - LATS1 (human)
Modsite: HQRCLAHsLVGTPNY SwissProt Entrez-Gene
Orthologous residues
LATS1 (human): S909‑p, LATS1 (mouse): S908‑p, LATS1 (rat): S909‑p
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

T967-p - LATS1 (human)
Modsite: MKVINWQtSLHIPPQ SwissProt Entrez-Gene
Orthologous residues
LATS1 (human): T967‑p, LATS1 (mouse): T966‑p, LATS1 (rat): T967‑p

T1012-p - LATS1 (human)
Modsite: kAHPFFKtIDFSSDL SwissProt Entrez-Gene
Orthologous residues
LATS1 (human): T1012‑p, LATS1 (mouse): T1011‑p, LATS1 (rat): T1012‑p

S1049-p - LATS1 (human)
Modsite: VDPDkLWsDDNEEEN SwissProt Entrez-Gene
Orthologous residues
LATS1 (human): S1049‑p, LATS1 (mouse): S1048‑p, LATS1 (rat): S1049‑p

T1060-p - LATS1 (human)
Modsite: EEENVNDtLNGWYKN SwissProt Entrez-Gene
Orthologous residues
LATS1 (human): T1060‑p, LATS1 (mouse): T1059‑p, LATS1 (rat): T1060‑p

T1079-p - LATS1 (human)
Modsite: EHAFyEFtFRRFFDD SwissProt Entrez-Gene
Orthologous residues
LATS1 (human): T1079‑p, LATS1 (mouse): T1078‑p, LATS1 (rat): T1079‑p
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

S1111-p - LATS1 (human)
Modsite: SQGsEQQsDEDDQNT SwissProt Entrez-Gene
Orthologous residues
LATS1 (human): S1111‑p, LATS1 (mouse): S1110‑p, LATS1 (rat): S1111‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human