El-Kady A, Klenova E (2005) Regulation of the transcription factor, CTCF, by phosphorylation with protein kinase CK2. FEBS Lett 579, 1424-34 15733852

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S612-p - CTCF (chicken) ▲

Modsite: KKEDssDsEENAEPD SwissProt Entrez-Gene Orthologous residues CTCF (human): S612‑p, CTCF (mouse): S612‑p, CTCF (rat): S612‑p, CTCF (chicken): S612‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  COS (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE CK2A1 (human) transfection of wild-type enzyme Downstream Regulation Effect of modification (function):  activity, inhibited Effect of modification (process):  transcription, induced Comments:  Phosphorylation mutant S612A inhibited transcriptional repression of transcription (CAT activity than wild-type CTCF.Phosphorylation mutant S612A showed transcriptional repression (CAT activity) not significantly different from wild-type after co-transfection with CK2.S612A also did not significanty alter growth suppression of COS7 cells in comparison with wild-type.