Curated Information
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Home > Curated Information Page > PubMed Id: 10330414
Blystone SD, et al. (1999) A molecular mechanism of integrin crosstalk: alphavbeta3 suppression of calcium/calmodulin-dependent protein kinase II regulates alpha5beta1 function. J Cell Biol 145, 889-97 10330414
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y773-p - ITGB3 (human)
Modsite: DtANNPLyKEAtstF SwissProt Entrez-Gene
Orthologous residues
ITGB3 (human): Y773‑p, ITGB3 iso2 (human): , ITGB3 (mouse): Y772‑p, ITGB3 (rat): Y772‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (process):  cell motility, altered

S778-p - ITGB3 (human)
Modsite: PLyKEAtstFTNIty SwissProt Entrez-Gene
Orthologous residues
ITGB3 (human): S778‑p, ITGB3 iso2 (human): , ITGB3 (mouse): S777‑p, ITGB3 (rat): S777‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  activity, inhibited
Effect of modification (process):  cell motility, altered
Comments:  regulates CamKII activity