Curated Information
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Home > Curated Information Page > PubMed Id: 16223874
Tanaka H, et al. (2005) DNA damage-induced phosphorylation of the human telomere-associated protein TRF2. Proc Natl Acad Sci U S A 102, 15539-44 16223874
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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S15-p - p53 (human)
Modsite: PsVEPPLsQEtFsDL SwissProt Entrez-Gene
Orthologous residues
p53 (human): S15‑p, p53 iso2 (human): S15‑p, p53 iso4 (human): , p53 (mouse): S18‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (green monkey): S15‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing_radiation increase
wortmannin ionizing_radiation inhibit treatment-induced increase

T230-p - TRF2 (human)
Modsite: HMSKDPttQkLRNDL SwissProt Entrez-Gene
Orthologous residues
TRF2 (human): T230‑p, TRF2 (mouse): T233‑p, TRF2 (rat): T188‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, phospho-antibody, phosphopeptide mapping, western blotting
Disease tissue studied:  brain cancer, glioblastoma, glioma, fibrosarcoma of soft tissue
Relevant cell lines - cell types - tissues:  BJ (fibroblast), HeLa (cervical), HT1080 (fibroblast), M059J (glial), M059K (glial), VA13 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing_radiation increase
wortmannin ionizing_radiation inhibit treatment-induced increase
etoposide, caffeine increase
etoposide increase In HT1080, BJE6/E7 and VA13 cells
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  TRF2 T188 localizes to telomeres iin crisis and associates with Double stranded breaks in photo-induced cells.