Curated Information
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Home > Curated Information Page > PubMed Id: 10938283
Lee HY, et al. (2000) Stress pathway activation induces phosphorylation of retinoid X receptor. J Biol Chem 275, 32193-9 10938283
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y249-p - RXRA (human)
Modsite: VEPKTETyVEANMGL SwissProt Entrez-Gene
Orthologous residues
RXRA (human): Y249‑p, RXRA (mouse): Y254‑p, RXRA (rat): Y254‑p
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey
Enzymes shown to modify site in vitro
Type Enzyme
KINASE MKK4 (human)
Downstream Regulation
Effect of modification (function):  activity, inhibited
Effect of modification (process):  transcription, altered
Comments:  Y249 phosphorylation is required for stress-induced suppression of retinoid signaling