Nakamura T, et al. (2005) Regulation of SR-BI protein levels by phosphorylation of its associated protein, PDZK1. Proc Natl Acad Sci U S A 102, 13404-9 16174736

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S509-p - PDZK1 (rat) ▲

Modsite: PARDRTLsAAsHsss SwissProt Entrez-Gene Orthologous residues PDZK1 (human): S505‑p, PDZK1 (mouse): S505‑p, PDZK1 (rat): S509‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Cellular systems studied:  cell lines, tissue Species studied:  hamster, rat Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKACA (human) pharmacological activator of upstream enzyme, pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes colforsin increase H-89 decrease glucagon increase Downstream Regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays SCARB1 (rat) Not reported electrophoretic visualization Comments:  phosphorylation of this site upregulates expression of SCARB1 protein