Curated Information
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Home > Curated Information Page > PubMed Id: 19104148
Kim KK, et al. (2009) Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 119, 213-24 19104148
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y654-p - CTNNB1 (human)
Modsite: RNEGVAtyAAAVLFR SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): Y654‑p, CTNNB1 (mouse): Y654‑p, CTNNB1 (rat): Y654‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'epithelial, lung', lung
Cellular systems studied:  primary cells, tissue
Species studied:  human, mouse
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cytoskeletal reorganization
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SMAD2 (human) Induces intracellular localization co-immunoprecipitation
SMAD2 (mouse) Induces intracellular localization co-immunoprecipitation
Comments:  nuclear accumulation in ideopathic pulmonary fibrosis (IPF) in lung
Associated Diseases
Diseases Alterations Comments
IPF increased accumulation of pY654–ß-catenin in myofibroblasts

Y654-p - CTNNB1 (mouse)
Modsite: RNEGVATyAAAVLFR SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): Y654‑p, CTNNB1 (mouse): Y654‑p, CTNNB1 (rat): Y654‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'epithelial, lung', lung
Cellular systems studied:  primary cells, tissue
Species studied:  human, mouse
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cytoskeletal reorganization
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SMAD2 (mouse) Induces intracellular localization co-immunoprecipitation
SMAD2 (human) Induces intracellular localization co-immunoprecipitation
Comments:  nuclear accumulation in ideopathic pulmonary fibrosis (IPF) in lung
Associated Diseases
Diseases Alterations Comments
IPF increased accumulation of pY654–ß-catenin in myofibroblasts