Yuzwa SA, et al. (2008) A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol 4, 483-90 18587388

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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T542-p - Tau (rat) ▲

Modsite: KKVAVVRtPPKsPSA SwissProt Entrez-Gene Orthologous residues Tau (human): T548‑p, Tau iso2 (human): T173‑p, Tau iso3 (human): T137‑p, Tau iso4 (human): T202‑p, Tau iso5 (human): T231‑p, Tau iso6 (human): T173‑p, Tau iso7 (human): T202‑p, Tau iso8 (human): T231‑p, Tau (mouse): T523‑p, Tau iso3 (mouse): T220‑p, Tau iso7 (mouse): T180‑p, Tau (rat): T542‑p, Tau (cow): T238‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  adrenal cancer, pheochromocytoma Relevant cell lines - cell types - tissues:  brain, PC-12 (chromaffin) Cellular systems studied:  cell lines, tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes thiamet-G decrease

S552-p - Tau (rat) ▲

Modsite: KsPSASKsRLQTAPV SwissProt Entrez-Gene Orthologous residues Tau (human): S558‑p, Tau iso2 (human): S183‑p, Tau iso3 (human): S147‑p, Tau iso4 (human): S212‑p, Tau iso5 (human): S241‑p, Tau iso6 (human): S183‑p, Tau iso7 (human): S212‑p, Tau iso8 (human): S241‑p, Tau (mouse): S533‑p, Tau iso3 (mouse): S230‑p, Tau iso7 (mouse): S190‑p, Tau (rat): S552‑p, Tau (cow): S248‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  adrenal cancer, pheochromocytoma Relevant cell lines - cell types - tissues:  brain, PC-12 (chromaffin) Cellular systems studied:  cell lines, tissue Species studied:  rat

S573-p - Tau (rat) ▲

Modsite: NVRSKIGsTENLKHQ SwissProt Entrez-Gene Orthologous residues Tau (human): S579‑p, Tau iso2 (human): S204‑p, Tau iso3 (human): S168‑p, Tau iso4 (human): S233‑p, Tau iso5 (human): S262‑p, Tau iso6 (human): S204‑p, Tau iso7 (human): S233‑p, Tau iso8 (human): S262‑p, Tau (mouse): S554‑p, Tau iso3 (mouse): S251‑p, Tau iso7 (mouse): S211‑p, Tau (rat): S573‑p, Tau (cow): S269‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  adrenal cancer, pheochromocytoma Relevant cell lines - cell types - tissues:  brain, PC-12 (chromaffin) Cellular systems studied:  cell lines, tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes thiamet-G no change compared to control

S707-p - Tau (rat) ▲

Modsite: GAEIVyKsPVVsGDt SwissProt Entrez-Gene Orthologous residues Tau (human): S713‑p, Tau iso2 (human): S307‑p, Tau iso3 (human): S271‑p, Tau iso4 (human): S336‑p, Tau iso5 (human): S365‑p, Tau iso6 (human): S338‑p, Tau iso7 (human): S367‑p, Tau iso8 (human): S396‑p, Tau (mouse): S688‑p, Tau iso3 (mouse): S385‑p, Tau iso7 (mouse): S345‑p, Tau (rat): S707‑p, Tau (cow): S403‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  adrenal cancer, pheochromocytoma Relevant cell lines - cell types - tissues:  brain, PC-12 (chromaffin) Cellular systems studied:  cell lines, tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes thiamet-G decrease

S715-p - Tau (rat) ▲

Modsite: PVVsGDtsPRHLSNV SwissProt Entrez-Gene Orthologous residues Tau (human): S721‑p, Tau iso2 (human): S315‑p, Tau iso3 (human): S279‑p, Tau iso4 (human): S344‑p, Tau iso5 (human): S373‑p, Tau iso6 (human): S346‑p, Tau iso7 (human): S375‑p, Tau iso8 (human): S404‑p, Tau (mouse): S696‑p, Tau iso3 (mouse): S393‑p, Tau iso7 (mouse): S353‑p, Tau (rat): S715‑p, Tau (cow): S411‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  adrenal cancer, pheochromocytoma Relevant cell lines - cell types - tissues:  brain, PC-12 (chromaffin) Cellular systems studied:  cell lines, tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes thiamet-G increase small increase

S733-p - Tau (rat) ▲

Modsite: GsIDMVDsPQLATLA SwissProt Entrez-Gene Orthologous residues Tau (human): S739‑p, Tau iso2 (human): S333‑p, Tau iso3 (human): S297‑p, Tau iso4 (human): S362‑p, Tau iso5 (human): S391‑p, Tau iso6 (human): S364‑p, Tau iso7 (human): S393‑p, Tau iso8 (human): S422‑p, Tau (mouse): S714‑p, Tau iso3 (mouse): S411‑p, Tau iso7 (mouse): S371‑p, Tau (rat): S733‑p, Tau (cow): S429‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  adrenal cancer, pheochromocytoma Relevant cell lines - cell types - tissues:  brain, PC-12 (chromaffin) Cellular systems studied:  cell lines, tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes thiamet-G decrease