Iwama A, Yamaguchi N, Suda T (1996) STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family. EMBO J 15, 5866-75 8918464

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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Y1330-p - Ron (mouse) ▲

Modsite: ASLLGDHyVQLTAAy SwissProt Entrez-Gene Orthologous residues Ron (human): Y1353‑p, Ron iso2 (human): Y1304‑p, Ron (mouse): Y1330‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor'), MEL (erythroid) Cellular systems studied:  cell lines Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes MSP increase Downstream Regulation Effect of modification (process):  apoptosis, induced, cell growth, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays PLCG1 (mouse) Induces in vitro, co-immunoprecipitation SHC1 (mouse) Induces in vitro, co-immunoprecipitation GRB2 (mouse) Induces in vitro, co-immunoprecipitation PIK3CA (mouse) Induces in vitro, co-immunoprecipitation

Y1337-p - Ron (mouse) ▲

Modsite: yVQLTAAyVNVGPRA SwissProt Entrez-Gene Orthologous residues Ron (human): Y1360‑p, Ron iso2 (human): Y1311‑p, Ron (mouse): Y1337‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor'), MEL (erythroid) Cellular systems studied:  cell lines Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes MSP increase Downstream Regulation Effect of modification (process):  apoptosis, induced, cell growth, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays SHC1 (mouse) Induces in vitro, co-immunoprecipitation PLCG1 (mouse) Induces in vitro, co-immunoprecipitation PIK3CA (mouse) Induces in vitro, co-immunoprecipitation GRB2 (mouse) Induces in vitro, co-immunoprecipitation