Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.4
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 16126371
Heinrich JN, et al. (2006) Disruption of ShcA signaling halts cell proliferation--characterization of ShcC residues that influence signaling pathways using yeast. Cell Signal 18, 795-806 16126371
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

Y218-p - SHC3 iso2 (human)
Modsite: GDGSDHPyyNSIPSK SwissProt Entrez-Gene
Orthologous residues
SHC3 (human): Y341‑p, SHC3 iso2 (human): Y218‑p, SHC3 (mouse): Y221‑p, SHC3 (rat): Y341‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Cellular systems studied:  cell lines
Species studied:  yeast

Y219-p - SHC3 iso2 (human)
Modsite: DGSDHPyyNSIPSKM SwissProt Entrez-Gene
Orthologous residues
SHC3 (human): Y342‑p, SHC3 iso2 (human): Y219‑p, SHC3 (mouse): Y222‑p, SHC3 (rat): Y342‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Cellular systems studied:  cell lines
Species studied:  yeast

Y301-p - SHC3 iso2 (human)
Modsite: PTGEAPTyVNTQQIP SwissProt Entrez-Gene
Orthologous residues
SHC3 (human): Y424‑p, SHC3 iso2 (human): Y301‑p, SHC3 (mouse): Y304‑p, SHC3 (rat): Y424‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Cellular systems studied:  cell lines
Species studied:  yeast
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
GRB2 (human) Induces yeast two-hybrid