Curated Information
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Home > Curated Information Page > PubMed Id: 16118249
Jensen J, et al. (2006) Muscle glycogen inharmoniously regulates glycogen synthase activity, glucose uptake, and proximal insulin signaling. Am J Physiol Endocrinol Metab 290, E154-E162 16118249
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S645-p - GYS1 (mouse)
Modsite: RPAsVPPsPsLsRHs SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S645‑p, GYS1 iso2 (human): S581‑p, GYS1 (mouse): S645‑p, GYS1 (rat): S645‑p, GYS1 (rabbit): S645‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  muscle
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin decrease
fasting decrease low glycogen condition

S649-p - GYS1 (mouse)
Modsite: VPPsPsLsRHssPHQ SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S649‑p, GYS1 iso2 (human): S585‑p, GYS1 (mouse): S649‑p, GYS1 (rat): S649‑p, GYS1 (rabbit): S649‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  muscle
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin decrease
fasting decrease low glycogen condition

S653-p - GYS1 (mouse)
Modsite: PsLsRHssPHQsEDE SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S653‑p, GYS1 iso2 (human): S589‑p, GYS1 (mouse): S653‑p, GYS1 (rat): S653‑p, GYS1 (rabbit): S653‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  muscle
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin decrease
fasting decrease low glycogen condition

S657-p - GYS1 (mouse)
Modsite: RHssPHQsEDEEEPR SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S657‑p, GYS1 iso2 (human): S593‑p, GYS1 (mouse): S657‑p, GYS1 (rat): S657‑p, GYS1 (rabbit): S657‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  muscle
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin decrease
fasting decrease low glycogen condition

S473-p - Akt1 (rat)
Modsite: RPHFPQFsYSASGTA SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  muscle
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
fasting insulin augment treatment-induced increase low glycogen condition

S21-p - GSK3A (rat)
Modsite: SGRARtssFAEPGGG SwissProt Entrez-Gene
Orthologous residues
GSK3A (human): S21‑p, GSK3A (mouse): S21‑p, GSK3A (rat): S21‑p, GSK3A (cow): S21‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  muscle
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
fasting insulin augment treatment-induced increase low glycogen condition

S9-p - GSK3B (rat)
Modsite: SGRPRTTsFAESCKP SwissProt Entrez-Gene
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S9‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  muscle
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
fasting insulin augment treatment-induced increase low glycogen condition