Curated Information
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Home > Curated Information Page > PubMed Id: 15741240
Ruzzin J, Jensen J (2005) Contraction activates glucose uptake and glycogen synthase normally in muscles from dexamethasone-treated rats. Am J Physiol Endocrinol Metab 289, E241-50 15741240
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S645-p - GYS1 (mouse)
Modsite: RPAsVPPsPsLsRHs SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S645‑p, GYS1 iso2 (human): S581‑p, GYS1 (mouse): S645‑p, GYS1 (rat): S645‑p, GYS1 (rabbit): S645‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
exercise decrease
insulin no change compared to control
dexamethasone no change compared to control
insulin, exercise decrease
dexamethasone, insulin, exercise decrease

S649-p - GYS1 (mouse)
Modsite: VPPsPsLsRHssPHQ SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S649‑p, GYS1 iso2 (human): S585‑p, GYS1 (mouse): S649‑p, GYS1 (rat): S649‑p, GYS1 (rabbit): S649‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
exercise decrease
insulin no change compared to control
dexamethasone no change compared to control
insulin, exercise decrease
dexamethasone, insulin, exercise decrease

S653-p - GYS1 (mouse)
Modsite: PsLsRHssPHQsEDE SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S653‑p, GYS1 iso2 (human): S589‑p, GYS1 (mouse): S653‑p, GYS1 (rat): S653‑p, GYS1 (rabbit): S653‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
exercise decrease
insulin no change compared to control
dexamethasone no change compared to control
insulin, exercise decrease
dexamethasone, insulin, exercise decrease

S657-p - GYS1 (mouse)
Modsite: RHssPHQsEDEEEPR SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S657‑p, GYS1 iso2 (human): S593‑p, GYS1 (mouse): S657‑p, GYS1 (rat): S657‑p, GYS1 (rabbit): S657‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
exercise decrease
insulin no change compared to control
dexamethasone no change compared to control
insulin, exercise decrease
dexamethasone, insulin, exercise decrease

S473-p - Akt1 (rat)
Modsite: RPHFPQFsYSASGTA SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
dexamethasone insulin inhibit treatment-induced increase
dexamethasone, exercise insulin inhibit treatment-induced increase

S9-p - GSK3B (rat)
Modsite: SGRPRTTsFAESCKP SwissProt Entrez-Gene
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S9‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
exercise increase
insulin exercise inhibit treatment-induced increase
dexamethasone exercise augment treatment-induced increase
insulin dexamethasone inhibit treatment-induced increase
dexamethasone increase