Curated Information
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Home > Curated Information Page > PubMed Id: 15988018
Fu Z, et al. (2005) Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase. Mol Cell Biol 25, 6047-64 15988018
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T157-p - ICK (mouse)
Modsite: IRSRPPytDyVStRW SwissProt Entrez-Gene
Orthologous residues
ICK (human): T157‑p, ICK iso2 (human): T157‑p, ICK (mouse): T157‑p, ICK (rat): T157‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mass spectrometry, phospho-antibody
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK7 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK7 (human) transfection of inactive enzyme, transfection of wild-type enzyme
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

Y159-p - ICK (mouse)
Modsite: SRPPytDyVStRWYR SwissProt Entrez-Gene
Orthologous residues
ICK (human): Y159‑p, ICK iso2 (human): Y159‑p, ICK (mouse): Y159‑p, ICK (rat): Y159‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mass spectrometry, phospho-antibody
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ICK (human) transfection of inactive enzyme
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced