Stawowy P, et al. (2005) Protein kinase C epsilon mediates angiotensin II-induced activation of beta1-integrins in cardiac fibroblasts. Cardiovasc Res 67, 50-9 15949469

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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T788-p - ITGB1 (human) ▲

Modsite: PIyksAVttVVNPky SwissProt Entrez-Gene Orthologous residues ITGB1 (human): T788‑p, ITGB1 iso2 (human): ‑, ITGB1 iso3 (human): ‑, ITGB1 iso5 (human): ‑, ITGB1 (mouse): T788‑p, ITGB1 iso5 (mouse): ‑, ITGB1 (rat): T789‑p, ITGB1 (hamster): T788‑p, ITGB1 (chicken): T793‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  cardiac Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKCE (human) genetic knockout/knockin of upstream enzyme, phospho-antibody, pharmacological inhibitor of upstream enzyme, microscopy-colocalization Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes calphostin_C angiotensin_2 inhibit treatment-induced increase phorbol_ester angiotensin_2 inhibit treatment-induced increase angiotensin_2 increase Downstream Regulation Effect of modification (process):  cell adhesion, altered

T789-p - ITGB1 (human) ▲

Modsite: IyksAVttVVNPkyE SwissProt Entrez-Gene Orthologous residues ITGB1 (human): T789‑p, ITGB1 iso2 (human): ‑, ITGB1 iso3 (human): ‑, ITGB1 iso5 (human): ‑, ITGB1 (mouse): T789‑p, ITGB1 iso5 (mouse): ‑, ITGB1 (rat): T790‑p, ITGB1 (hamster): T789‑p, ITGB1 (chicken): T794‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  cardiac Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKCE (human) genetic knockout/knockin of upstream enzyme, phospho-antibody, pharmacological inhibitor of upstream enzyme, microscopy-colocalization Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes calphostin_C angiotensin_2 inhibit treatment-induced increase phorbol_ester angiotensin_2 inhibit treatment-induced increase angiotensin_2 increase Downstream Regulation Effect of modification (process):  cell adhesion, altered

S657-p - PKCA (human) ▲
Modsite: QsDFEGFsyVNPQFV SwissProt Entrez-Gene Orthologous residues PKCA (human): S657‑p, PKCA (mouse): S657‑p, PKCA (rat): S657‑p, PKCA (cow): S657‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  cardiac Cellular systems studied:  cell lines Species studied:  rat

T507-p - PKCD (human) ▲
Modsite: FGEsRAstFCGtPDy SwissProt Entrez-Gene Orthologous residues PKCD (human): T507‑p, PKCD iso2 (human): T538‑p, PKCD (mouse): T505‑p, PKCD iso2 (mouse): T531‑p, PKCD (rat): T505‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  cardiac Cellular systems studied:  cell lines Species studied:  rat

S729-p - PKCE (human) ▲

Modsite: QEEFKGFsYFGEDLM SwissProt Entrez-Gene Orthologous residues PKCE (human): S729‑p, PKCE (mouse): S729‑p, PKCE (rat): S729‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  cardiac Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes angiotensin_2 increase