Curated Information
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Home > Curated Information Page > PubMed Id: 15949469
Stawowy P, et al. (2005) Protein kinase C epsilon mediates angiotensin II-induced activation of beta1-integrins in cardiac fibroblasts. Cardiovasc Res 67, 50-9 15949469
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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T788-p - ITGB1 (human)
Modsite: PIyksAVttVVNPky SwissProt Entrez-Gene
Orthologous residues
ITGB1 (human): T788‑p, ITGB1 iso2 (human): , ITGB1 iso3 (human): , ITGB1 iso5 (human): , ITGB1 (mouse): T788‑p, ITGB1 iso5 (mouse): , ITGB1 (rat): T789‑p, ITGB1 (hamster): T788‑p, ITGB1 (chicken): T793‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  cardiac
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCE (human) microscopy-colocalization, phospho-antibody, genetic knockout/knockin of upstream enzyme, pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
calphostin_C angiotensin_2 inhibit treatment-induced increase
phorbol_ester angiotensin_2 inhibit treatment-induced increase
angiotensin_2 increase

T789-p - ITGB1 (human)
Modsite: IyksAVttVVNPkyE SwissProt Entrez-Gene
Orthologous residues
ITGB1 (human): T789‑p, ITGB1 iso2 (human): , ITGB1 iso3 (human): , ITGB1 iso5 (human): , ITGB1 (mouse): T789‑p, ITGB1 iso5 (mouse): , ITGB1 (rat): T790‑p, ITGB1 (hamster): T789‑p, ITGB1 (chicken): T794‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  cardiac
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCE (human) microscopy-colocalization, phospho-antibody, genetic knockout/knockin of upstream enzyme, pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
calphostin_C angiotensin_2 inhibit treatment-induced increase
phorbol_ester angiotensin_2 inhibit treatment-induced increase
angiotensin_2 increase

S657-p - PKCA (human)
Modsite: QsDFEGFsyVNPQFV SwissProt Entrez-Gene
Orthologous residues
PKCA (human): S657‑p, PKCA (mouse): S657‑p, PKCA (rat): S657‑p, PKCA (cow): S657‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  cardiac
Cellular systems studied:  cell lines
Species studied:  rat

T507-p - PKCD (human)
Modsite: FGEsRAstFCGtPDy SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T507‑p, PKCD iso2 (human): T538‑p, PKCD (mouse): T505‑p, PKCD iso2 (mouse): T531‑p, PKCD (rat): T505‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  cardiac
Cellular systems studied:  cell lines
Species studied:  rat

S729-p - PKCE (human)
Modsite: QEEFKGFsYFGEDLM SwissProt Entrez-Gene
Orthologous residues
PKCE (human): S729‑p, PKCE (mouse): S729‑p, PKCE (rat): S729‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  cardiac
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
angiotensin_2 increase