Curated Information
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Home > Curated Information Page > PubMed Id: 16014723
Wittmack EK, et al. (2005) Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase. J Neurosci 25, 6621-30 16014723
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S553-p - SCN8A (mouse)
Modsite: SLLSIPGsPFLSRHN SwissProt Entrez-Gene
Orthologous residues
SCN8A (human): S553‑p, SCN8A iso3 (human): S553‑p, SCN8A (mouse): S553‑p, SCN8A (rat): S553‑p

S553-p - SCN8A (rat)
Modsite: SLLSIPGsPFLSRHN SwissProt Entrez-Gene
Orthologous residues
SCN8A (human): S553‑p, SCN8A iso3 (human): S553‑p, SCN8A (mouse): S553‑p, SCN8A (rat): S553‑p
Characterization
Methods used to characterize site in vivo microscopy-colocalization with upstream kinase, mutation of modification site
Cellular systems studied:  cell lines
Species studied:  rat
Enzymes shown to modify site in vitro
Type Enzyme
KINASE P38A (mouse)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anisomycin decrease Anisomycin reduces peak current density and is bloicked in S553A mutant.