Curated Information
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Yamamoto H, et al. (2005) Phosphorylation of tau at serine 416 by Ca2+/calmodulin-dependent protein kinase II in neuronal soma in brain. J Neurochem 94, 1438-47 16000144
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S416-p - Tau iso8 (human)
Modsite: sNVsstGsIDMVDsP SwissProt Entrez-Gene
Orthologous residues
Tau (human): S733‑p, Tau iso2 (human): S327‑p, Tau iso3 (human): S291‑p, Tau iso4 (human): S356‑p, Tau iso5 (human): S385‑p, Tau iso6 (human): S358‑p, Tau iso7 (human): S387‑p, Tau iso8 (human): S416‑p, Tau (mouse): S708‑p, Tau iso3 (mouse): S405‑p, Tau iso7 (mouse): S365‑p, Tau (rat): S727‑p, Tau (cow): S423‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  'brain, cerebral cortex'
Cellular systems studied:  tissue
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CAMK2A (human)

S510-p - Tau (rat)
Modsite: GERSGyssPGsPGtP SwissProt Entrez-Gene
Orthologous residues
Tau (human): S516‑p, Tau iso2 (human): S141‑p, Tau iso3 (human): S105‑p, Tau iso4 (human): S170‑p, Tau iso5 (human): S199‑p, Tau iso6 (human): S141‑p, Tau iso7 (human): S170‑p, Tau iso8 (human): S199‑p, Tau (mouse): S491‑p, Tau iso3 (mouse): S188‑p, Tau iso7 (mouse): S148‑p, Tau (rat): S510‑p, Tau (cow): S206‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Cellular systems studied:  tissue
Species studied:  rat

S513-p - Tau (rat)
Modsite: SGyssPGsPGtPGsR SwissProt Entrez-Gene
Orthologous residues
Tau (human): S519‑p, Tau iso2 (human): S144‑p, Tau iso3 (human): S108‑p, Tau iso4 (human): S173‑p, Tau iso5 (human): S202‑p, Tau iso6 (human): S144‑p, Tau iso7 (human): S173‑p, Tau iso8 (human): S202‑p, Tau (mouse): S494‑p, Tau iso3 (mouse): S191‑p, Tau iso7 (mouse): S151‑p, Tau (rat): S513‑p, Tau (cow): S209‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Cellular systems studied:  tissue
Species studied:  rat

S707-p - Tau (rat)
Modsite: GAEIVyKsPVVsGDt SwissProt Entrez-Gene
Orthologous residues
Tau (human): S713‑p, Tau iso2 (human): S307‑p, Tau iso3 (human): S271‑p, Tau iso4 (human): S336‑p, Tau iso5 (human): S365‑p, Tau iso6 (human): S338‑p, Tau iso7 (human): S367‑p, Tau iso8 (human): S396‑p, Tau (mouse): S688‑p, Tau iso3 (mouse): S385‑p, Tau iso7 (mouse): S345‑p, Tau (rat): S707‑p, Tau (cow): S403‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Cellular systems studied:  tissue
Species studied:  rat

S727-p - Tau (rat)
Modsite: SNVssTGsIDMVDsP SwissProt Entrez-Gene
Orthologous residues
Tau (human): S733‑p, Tau iso2 (human): S327‑p, Tau iso3 (human): S291‑p, Tau iso4 (human): S356‑p, Tau iso5 (human): S385‑p, Tau iso6 (human): S358‑p, Tau iso7 (human): S387‑p, Tau iso8 (human): S416‑p, Tau (mouse): S708‑p, Tau iso3 (mouse): S405‑p, Tau iso7 (mouse): S365‑p, Tau (rat): S727‑p, Tau (cow): S423‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Cellular systems studied:  tissue
Species studied:  rat

S423-p - Tau (cow)
Modsite: SNVSSTGsIDMVDSP SwissProt Entrez-Gene
Orthologous residues
Tau (human): S733‑p, Tau iso2 (human): S327‑p, Tau iso3 (human): S291‑p, Tau iso4 (human): S356‑p, Tau iso5 (human): S385‑p, Tau iso6 (human): S358‑p, Tau iso7 (human): S387‑p, Tau iso8 (human): S416‑p, Tau (mouse): S708‑p, Tau iso3 (mouse): S405‑p, Tau iso7 (mouse): S365‑p, Tau (rat): S727‑p, Tau (cow): S423‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Cellular systems studied:  tissue
Species studied:  cow
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CAMK2A (human)