Curated Information
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Home > Curated Information Page > PubMed Id: 12138184
Barnes BJ, Kellum MJ, Field AE, Pitha PM (2002) Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes. Mol Cell Biol 22, 5721-40 12138184
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S435-p - IRF5 (human)
Modsite: EMFSGELsWsADsIR SwissProt Entrez-Gene
Orthologous residues
IRF5 (human): S435‑p, IRF5 iso2 (human): S451‑p, IRF5 (mouse): S434‑p, IRF5 (rat): S434‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  2fTGH (fibroblast)
Cellular systems studied:  cell lines
Species studied:  human

S437-p - IRF5 (human)
Modsite: FSGELsWsADsIRLQ SwissProt Entrez-Gene
Orthologous residues
IRF5 (human): S437‑p, IRF5 iso2 (human): S453‑p, IRF5 (mouse): S436‑p, IRF5 (rat): S436‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  2fTGH (fibroblast)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (process):  transcription, induced

S440-p - IRF5 (human)
Modsite: ELsWsADsIRLQIsN SwissProt Entrez-Gene
Orthologous residues
IRF5 (human): S440‑p, IRF5 iso2 (human): S456‑p, IRF5 (mouse): S439‑p, IRF5 (rat): S439‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  2fTGH (fibroblast)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (process):  transcription, induced