Curated Information
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Home > Curated Information Page > PubMed Id: 11509654
Eapen AK, Henry MK, Quelle DE, Quelle FW (2001) Dna damage-induced G(1) arrest in hematopoietic cells is overridden following phosphatidylinositol 3-kinase-dependent activation of cyclin-dependent kinase 2. Mol Cell Biol 21, 6113-21 11509654
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y15-p - CDK2 (mouse)
Modsite: EKIGEGtyGVVyKAK SwissProt Entrez-Gene
Orthologous residues
CDK2 (human): Y15‑p, CDK2 iso2 (human): Y15‑p, CDK2 (mouse): Y15‑p, CDK2 (rat): Y15‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  32D (myeloid) [IRS1 (mouse)], 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IL-3 increase
Epo increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, inhibited
Effect of modification (process):  cell growth, altered

T160-p - CDK2 (mouse)
Modsite: GVPVRtYtHEVVTLW SwissProt Entrez-Gene
Orthologous residues
CDK2 (human): T160‑p, CDK2 iso2 (human): T160‑p, CDK2 (mouse): T160‑p, CDK2 (rat): T160‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  32D (myeloid) [IRS1 (mouse)], 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IL-3 increase
ionizing_radiation IL-3 inhibit treatment-induced increase
LY294002 IL-3 inhibit treatment-induced increase
Epo increase
ionizing_radiation Epo inhibit treatment-induced increase
LY294002 Epo inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced