Curated Information
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Home > Curated Information Page > PubMed Id: 29786073
Jung SH, et al. (2018) Integrin α6β4-Src-AKT signaling induces cellular senescence by counteracting apoptosis in irradiated tumor cells and tissues. Cell Death Differ 29786073
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S274-p - ZNF24 (mouse)
Modsite: ILHQRIHsGEKPYGC SwissProt Entrez-Gene
Orthologous residues
ZNF24 (human): S274‑p, ZNF24 (mouse): S274‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), oligodendrocyte precursor
Cellular systems studied:  primary cells
Species studied:  mouse, rat
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell differentiation, inhibited, transcription, inhibited
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Disrupts cell differentiation, inhibited EMSA
Comments:  regulates oligodendrocyte differentiation and CNS myelination

T302-p - ZNF24 (mouse)
Modsite: VQHQRVHtGEKPYKC SwissProt Entrez-Gene
Orthologous residues
ZNF24 (human): T302‑p, ZNF24 (mouse): T302‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), oligodendrocyte precursor
Cellular systems studied:  primary cells
Species studied:  mouse, rat
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell differentiation, inhibited, transcription, inhibited
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Disrupts cell differentiation, inhibited EMSA
Comments:  regulates oligodendrocyte differentiation and CNS myelination

T330-p - ZNF24 (mouse)
Modsite: INHQRIHtGEKPYEC SwissProt Entrez-Gene
Orthologous residues
ZNF24 (human): T330‑p, ZNF24 (mouse): T330‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), oligodendrocyte precursor
Cellular systems studied:  primary cells
Species studied:  mouse, rat
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell differentiation, inhibited, transcription, inhibited
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Disrupts cell differentiation, inhibited EMSA
Comments:  regulates oligodendrocyte differentiation and CNS myelination