Shah N, et al. (2018) TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth. Nat Commun 9, 1696 29703898

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S237-p - ATAT1 (human) ▲

Modsite: GDIkPYSsSDREFLK SwissProt Entrez-Gene Orthologous residues ATAT1 (human): S237‑p, ATAT1 (mouse): S237‑p, ATAT1 iso2 (mouse): S214‑p, ATAT1 (rat): S237‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  COS7 (fibroblast), HeLa (cervical), MEF (fibroblast) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE TAK1 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE TAK1 (human) co-immunoprecipitation, phospho-antibody, pharmacological inhibitor of upstream enzyme, activation of upstream enzyme Downstream Regulation Effect of modification (function):  acetylation, enzymatic activity, induced Effect of modification (process):  cell growth, inhibited