Lindgren N, et al. (2001) Dopamine D(2) receptors regulate tyrosine hydroxylase activity and phosphorylation at Ser40 in rat striatum. Eur J Neurosci 13, 773-80 11207812

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S19-p - TH (rat) ▲

Modsite: KGFRRAVsEQDAKQA SwissProt Entrez-Gene Orthologous residues TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  'brain, striatum' Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes okadaic_acid increase quinpirole okadaic_acid no effect upon treatment-induced increase quinpirole no change compared to control NMDA increase eticlopride NMDA no effect upon treatment-induced increase

S31-p - TH (rat) ▲

Modsite: KQAEAVTsPRFIGRR SwissProt Entrez-Gene Orthologous residues TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  'brain, striatum' Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes quinpirole no change compared to control okadaic_acid no change compared to control okadaic_acid quinpirole no change compared to control

S40-p - TH (rat) ▲

Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene Orthologous residues TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  'brain, striatum' Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes quinpirole decrease eticlopride quinpirole inhibit treatment-induced decrease colforsin increase quinpirole colforsin inhibit treatment-induced increase okadaic_acid increase quinpirole okadaic_acid inhibit treatment-induced increase Ro-20-1724 increase quinpirole Ro-20-1724 inhibit treatment-induced increase cAMP_analog increase quinpirole cAMP_analog no effect upon treatment-induced increase