Chen S, Gulla S, Cai C, Balk SP (2012) Androgen receptor serine 81 phosphorylation mediates chromatin binding and transcriptional activation. J Biol Chem 287, 8571-83 22275373

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S83-p - AR (human) ▲

Modsite: QQQQQEtsPRQQQQQ SwissProt Entrez-Gene Orthologous residues AR (human): S83‑p, AR iso3 (human): S83‑p, AR (mouse): S61‑p, AR (rat): S61‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  LNCaP (prostate cell), PC3 (prostate cell) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE CDK9 (human) phospho-antibody, pharmacological inhibitor of upstream enzyme in non mitotic cells KINASE CDK1 (human) phospho-antibody, pharmacological inhibitor of upstream enzyme in mitotic cells Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes nocodazole increase RO-3306 nocodazole inhibit treatment-induced increase CGP74514A nocodazole inhibit treatment-induced increase androstanolone increase hydroxyurea androstanolone no effect upon treatment-induced increase mimosine androstanolone no effect upon treatment-induced increase Downstream Regulation Effect of modification (function):  activity, induced, molecular association, regulation Effect of modification (process):  transcription, induced Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays Induces Comments:  Induced transcription of endogenous genes

S516-p - AR (human) ▲
Modsite: VSRVPYPsPTCVkSE SwissProt Entrez-Gene Orthologous residues AR (human): S516‑p, AR iso3 (human): S516‑p, AR (mouse): S495‑p, AR (rat): S498‑p