Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 12719581
Johnston JB, et al. (2003) Role of the serine-threonine kinase PAK-1 in myxoma virus replication. J Virol 77, 5877-88 12719581
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

S338-p - RAF1 (human)
Modsite: RPRGQRDssyyWEIE SwissProt Entrez-Gene
Orthologous residues
RAF1 (human): S338‑p, RAF1 iso2 (human): S358‑p, RAF1 (mouse): S338‑p, RAF1 (rat): S338‑p, RAF1 (chicken): S338‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
virus infection increase myxoma virus infection induced greater activation of Raf1 in cells permissive for viral replication than in restrictive cells.
IFN-gamma increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

T423-p - PAK1 (mouse)
Modsite: PEQSKRstMVGtPYW SwissProt Entrez-Gene
Orthologous residues
PAK1 (human): T423‑p, PAK1 (mouse): T423‑p, PAK1 (rat): T422‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
virus infection increase myxoma virus infection activated PAK1 more strongly in cells permissive for viral replication than in restrictive cells.
IFN-gamma increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced