Curated Information
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Home > Curated Information Page > PubMed Id: 15647282
Yook JI, et al. (2005) Wnt-dependent regulation of the E-cadherin repressor snail. J Biol Chem 280, 11740-8 15647282
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S96-p - Snail1 (human)
Modsite: TsLsDEDsGKGsQPP SwissProt Entrez-Gene
Orthologous residues
Snail1 (human): S96‑p, Snail1 (mouse): S96‑p
Downstream Regulation
Effect of modification (function):  protein degradation

S104-p - Snail1 (human)
Modsite: GKGsQPPsPPsPAPs SwissProt Entrez-Gene
Orthologous residues
Snail1 (human): S104‑p, Snail1 (mouse): S104‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (human) pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lithium decrease
Downstream Regulation
Effect of modification (function):  protein degradation

S107-p - Snail1 (human)
Modsite: sQPPsPPsPAPssFS SwissProt Entrez-Gene
Orthologous residues
Snail1 (human): S107‑p, Snail1 (mouse): S107‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (human) pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lithium decrease
Downstream Regulation
Effect of modification (function):  protein degradation