Curated Information
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Home > Curated Information Page > PubMed Id: 28424242
Chornoguz O, et al. (2017) mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation. J Immunol 198, 3939-3948 28424242
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S52-p - TBX21 (mouse)
Modsite: TDRRAGSsLGtPYSG SwissProt Entrez-Gene
Orthologous residues
TBX21 (human): S53‑p, TBX21 (mouse): S52‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site
Relevant cell lines - cell types - tissues:  T lymphocyte-spleen
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
rapamycin decrease

T55-p - TBX21 (mouse)
Modsite: RAGSsLGtPYSGGAL SwissProt Entrez-Gene
Orthologous residues
TBX21 (human): S56‑p, TBX21 (mouse): T55‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site
Relevant cell lines - cell types - tissues:  T lymphocyte-spleen
Cellular systems studied:  cell lines
Species studied:  mouse

Y76-p - TBX21 (mouse)
Modsite: RFLGSFAyPPRAQVA SwissProt Entrez-Gene
Orthologous residues
TBX21 (human): Y77‑p, TBX21 (mouse): Y76‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site
Relevant cell lines - cell types - tissues:  T lymphocyte-spleen
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
rapamycin decrease

Y117-p - TBX21 (mouse)
Modsite: PDPRAGLyPGPREDY SwissProt Entrez-Gene
Orthologous residues
TBX21 (human): Y118‑p, TBX21 (mouse): Y117‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site
Relevant cell lines - cell types - tissues:  T lymphocyte-spleen
Cellular systems studied:  cell lines
Species studied:  mouse

S224-p - TBX21 (mouse)
Modsite: RLYVHPDsPNTGAHW SwissProt Entrez-Gene
Orthologous residues
TBX21 (human): S225‑p, TBX21 (mouse): S224‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site
Relevant cell lines - cell types - tissues:  T lymphocyte-spleen
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
rapamycin decrease

S508-p - TBX21 (mouse)
Modsite: PsSGDSSsPAGAPsP SwissProt Entrez-Gene
Orthologous residues
TBX21 (human): S513‑p, TBX21 (mouse): S508‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site
Relevant cell lines - cell types - tissues:  T lymphocyte-spleen
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
rapamycin decrease

S514-p - TBX21 (mouse)
Modsite: SsPAGAPsPFDKETE SwissProt Entrez-Gene
Orthologous residues
TBX21 (human): S519‑p, TBX21 (mouse): S514‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site
Relevant cell lines - cell types - tissues:  T lymphocyte-spleen
Cellular systems studied:  cell lines
Species studied:  mouse