Du C, Jaggi M, Zhang C, Balaji KC (2009) Protein kinase D1-mediated phosphorylation and subcellular localization of beta-catenin. Cancer Res 69, 1117-24 19141652

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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T102-p - CTNNB1 (human) ▲
Modsite: RAAMFPEtLDEGMQI SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): T102‑p, CTNNB1 (mouse): T102‑p, CTNNB1 (rat): T102‑p, CTNNB1 (rabbit): T102‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human

T112-p - CTNNB1 (human) ▲

Modsite: EGMQIPstQFdAAHP SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): T112‑p, CTNNB1 (mouse): T112‑p, CTNNB1 (rat): T112‑p, CTNNB1 (rabbit): T112‑p Characterization Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  3T3 (fibroblast), HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human, mouse Enzymes shown to modify site in vitro:  Type Enzyme KINASE PRKD1 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PRKD1 (human) electrophoretic mobility shift, transfection of wild-type enzyme, co-immunoprecipitation Downstream Regulation Effect of modification (function):  intracellular localization Effect of modification (process):  cell growth, inhibited, cell motility, inhibited, transcription, induced

T120-p - CTNNB1 (human) ▲

Modsite: QFdAAHPtNVQRLAE SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): T120‑p, CTNNB1 (mouse): T120‑p, CTNNB1 (rat): T120‑p, CTNNB1 (rabbit): T120‑p Characterization Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  3T3 (fibroblast), HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human, mouse Enzymes shown to modify site in vitro:  Type Enzyme KINASE PRKD1 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PRKD1 (human) electrophoretic mobility shift, transfection of wild-type enzyme, co-immunoprecipitation Downstream Regulation Effect of modification (function):  intracellular localization Effect of modification (process):  cell growth, inhibited, cell motility, inhibited, transcription, induced