Curated Information
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Home > Curated Information Page > PubMed Id: 19141652
Du C, Jaggi M, Zhang C, Balaji KC (2009) Protein kinase D1-mediated phosphorylation and subcellular localization of beta-catenin. Cancer Res 69, 1117-24 19141652
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T102-p - CTNNB1 (human)
Modsite: RAAMFPEtLDEGMQI SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): T102‑p, CTNNB1 (mouse): T102‑p, CTNNB1 (rat): T102‑p

T112-p - CTNNB1 (human)
Modsite: EGMQIPStQFdAAHP SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): T112‑p, CTNNB1 (mouse): T112‑p, CTNNB1 (rat): T112‑p
Characterization
Methods used to characterize site in vivo electrophoretic mobility shift, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  3T3 (fibroblast), HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PRKD1 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PRKD1 (human) co-immunoprecipitation, transfection of wild-type enzyme, electrophoretic mobility shift
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  cell growth, inhibited, cell motility, inhibited, transcription, induced

T120-p - CTNNB1 (human)
Modsite: QFdAAHPtNVQRLAE SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): T120‑p, CTNNB1 (mouse): T120‑p, CTNNB1 (rat): T120‑p
Characterization
Methods used to characterize site in vivo electrophoretic mobility shift, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  3T3 (fibroblast), HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PRKD1 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PRKD1 (human) co-immunoprecipitation, transfection of wild-type enzyme, electrophoretic mobility shift
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  cell growth, inhibited, cell motility, inhibited, transcription, induced