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Home > Curated Information Page > PubMed Id: 15992372
Liu R, et al. (2005) Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms. J Neurochem 94, 1225-34 15992372
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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T203-p - ERK1 (rat)
Modsite: HDHTGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): T202‑p, ERK1 iso2 (human): T202‑p, ERK1 iso3 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia decrease

Y205-p - ERK1 (rat)
Modsite: HTGFLtEyVAtRWYR SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia decrease

T183-p - ERK2 (rat)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p, ERK2 (cow): T185‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia decrease

Y185-p - ERK2 (rat)
Modsite: HtGFLtEyVAtRWYR SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia decrease

T183-p - JNK1 (rat)
Modsite: AGTsFMMtPyVVtRY SwissProt Entrez-Gene
Orthologous residues
JNK1 (human): T183‑p, JNK1 iso2 (human): T183‑p, JNK1 iso3 (human): T183‑p, JNK1 (mouse): T183‑p, JNK1 (rat): T183‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia decrease

Y185-p - JNK1 (rat)
Modsite: TsFMMtPyVVtRYYR SwissProt Entrez-Gene
Orthologous residues
JNK1 (human): Y185‑p, JNK1 iso2 (human): Y185‑p, JNK1 iso3 (human): Y185‑p, JNK1 (mouse): Y185‑p, JNK1 (rat): Y185‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia decrease

T183-p - JNK2 (rat)
Modsite: ACTNFMMtPyVVTRY SwissProt Entrez-Gene
Orthologous residues
JNK2 (human): T183‑p, JNK2 iso2 (human): T183‑p, JNK2 iso3 (human): T183‑p, JNK2 (mouse): T183‑p, JNK2 (rat): T183‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia decrease

Y185-p - JNK2 (rat)
Modsite: TNFMMtPyVVTRYYR SwissProt Entrez-Gene
Orthologous residues
JNK2 (human): Y185‑p, JNK2 iso2 (human): Y185‑p, JNK2 iso3 (human): Y185‑p, JNK2 (mouse): Y185‑p, JNK2 (rat): Y185‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia decrease

Y307-p - PPP2CA (rat)
Modsite: VTRRTPDyFl_____ SwissProt Entrez-Gene
Orthologous residues
PPP2CA (human): Y307‑p, PPP2CA iso2 (human): Y253‑p, PPP2CA (mouse): Y307‑p, PPP2CA (rat): Y307‑p, PPP2CA (pig): Y307‑p, PPP2CA (cow): Y307‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia decrease

T492-p - Tau (rat)
Modsite: KtTPsPKtPPGSGEP SwissProt Entrez-Gene
Orthologous residues
Tau (human): T498‑p, Tau iso2 (human): T123‑p, Tau iso3 (human): T87‑p, Tau iso4 (human): T152‑p, Tau iso5 (human): T181‑p, Tau iso6 (human): T123‑p, Tau iso7 (human): T152‑p, Tau iso8 (human): T181‑p, Tau (mouse): T473‑p, Tau iso3 (mouse): T170‑p, Tau iso7 (mouse): T112‑p, Tau (rat): T492‑p, Tau (cow): T172‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia decrease

S510-p - Tau (rat)
Modsite: GERSGyssPGsPGtP SwissProt Entrez-Gene
Orthologous residues
Tau (human): S516‑p, Tau iso2 (human): S141‑p, Tau iso3 (human): S105‑p, Tau iso4 (human): S170‑p, Tau iso5 (human): S199‑p, Tau iso6 (human): S141‑p, Tau iso7 (human): S170‑p, Tau iso8 (human): S199‑p, Tau (mouse): S491‑p, Tau iso3 (mouse): S188‑p, Tau iso7 (mouse): S148‑p, Tau (rat): S510‑p, Tau (cow): S206‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia decrease
low_glucose no change compared to control

S513-p - Tau (rat)
Modsite: SGyssPGsPGtPGsR SwissProt Entrez-Gene
Orthologous residues
Tau (human): S519‑p, Tau iso2 (human): S144‑p, Tau iso3 (human): S108‑p, Tau iso4 (human): S173‑p, Tau iso5 (human): S202‑p, Tau iso6 (human): S144‑p, Tau iso7 (human): S173‑p, Tau iso8 (human): S202‑p, Tau (mouse): S494‑p, Tau iso3 (mouse): S191‑p, Tau iso7 (mouse): S151‑p, Tau (rat): S513‑p, Tau (cow): S209‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia decrease
low_glucose no change compared to control

T516-p - Tau (rat)
Modsite: ssPGsPGtPGsRSRt SwissProt Entrez-Gene
Orthologous residues
Tau (human): T522‑p, Tau iso2 (human): T147‑p, Tau iso3 (human): T111‑p, Tau iso4 (human): T176‑p, Tau iso5 (human): T205‑p, Tau iso6 (human): T147‑p, Tau iso7 (human): T176‑p, Tau iso8 (human): T205‑p, Tau (mouse): T497‑p, Tau iso3 (mouse): T194‑p, Tau iso7 (mouse): T154‑p, Tau (rat): T516‑p, Tau (cow): T212‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia decrease

T542-p - Tau (rat)
Modsite: KKVAVVRtPPKsPSA SwissProt Entrez-Gene
Orthologous residues
Tau (human): T548‑p, Tau iso2 (human): T173‑p, Tau iso3 (human): T137‑p, Tau iso4 (human): T202‑p, Tau iso5 (human): T231‑p, Tau iso6 (human): T173‑p, Tau iso7 (human): T202‑p, Tau iso8 (human): T231‑p, Tau (mouse): T523‑p, Tau iso3 (mouse): T220‑p, Tau iso7 (mouse): T180‑p, Tau (rat): T542‑p, Tau (cow): T238‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia decrease

S573-p - Tau (rat)
Modsite: NVRSKIGsTENLKHQ SwissProt Entrez-Gene
Orthologous residues
Tau (human): S579‑p, Tau iso2 (human): S204‑p, Tau iso3 (human): S168‑p, Tau iso4 (human): S233‑p, Tau iso5 (human): S262‑p, Tau iso6 (human): S204‑p, Tau iso7 (human): S233‑p, Tau iso8 (human): S262‑p, Tau (mouse): S554‑p, Tau iso3 (mouse): S251‑p, Tau iso7 (mouse): S211‑p, Tau (rat): S573‑p, Tau (cow): S269‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia no change compared to control

S707-p - Tau (rat)
Modsite: GAEIVyKsPVVsGDt SwissProt Entrez-Gene
Orthologous residues
Tau (human): S713‑p, Tau iso2 (human): S307‑p, Tau iso3 (human): S271‑p, Tau iso4 (human): S336‑p, Tau iso5 (human): S365‑p, Tau iso6 (human): S338‑p, Tau iso7 (human): S367‑p, Tau iso8 (human): S396‑p, Tau (mouse): S688‑p, Tau iso3 (mouse): S385‑p, Tau iso7 (mouse): S345‑p, Tau (rat): S707‑p, Tau (cow): S403‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia decrease
low_glucose no change compared to control

S715-p - Tau (rat)
Modsite: PVVsGDtsPRHLSNV SwissProt Entrez-Gene
Orthologous residues
Tau (human): S721‑p, Tau iso2 (human): S315‑p, Tau iso3 (human): S279‑p, Tau iso4 (human): S344‑p, Tau iso5 (human): S373‑p, Tau iso6 (human): S346‑p, Tau iso7 (human): S375‑p, Tau iso8 (human): S404‑p, Tau (mouse): S696‑p, Tau iso3 (mouse): S393‑p, Tau iso7 (mouse): S353‑p, Tau (rat): S715‑p, Tau (cow): S411‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia decrease
low_glucose no change compared to control

S733-p - Tau (rat)
Modsite: GsIDMVDsPQLATLA SwissProt Entrez-Gene
Orthologous residues
Tau (human): S739‑p, Tau iso2 (human): S333‑p, Tau iso3 (human): S297‑p, Tau iso4 (human): S362‑p, Tau iso5 (human): S391‑p, Tau iso6 (human): S364‑p, Tau iso7 (human): S393‑p, Tau iso8 (human): S422‑p, Tau (mouse): S714‑p, Tau iso3 (mouse): S411‑p, Tau iso7 (mouse): S371‑p, Tau (rat): S733‑p, Tau (cow): S429‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain
Cellular systems studied:  tissue
Species studied:  rat
Comments:  coronal slices
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anoxia decrease