Curated Information
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Home > Curated Information Page > PubMed Id: 28296173
Chang R, Zhang Y, Zhang P, Zhou Q (2017) Snail acetylation by histone acetyltransferase p300 in lung cancer. Thorac Cancer 8, 131-137 28296173
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K187-ac - Snail1 (human)
Modsite: CVCGTCGkAFSRPWL SwissProt Entrez-Gene
Orthologous residues
Snail1 (human): K187‑ac, Snail1 (mouse): K187‑ac
Characterization
Methods used to characterize site in vivo [14C] acetate labeling, immunoprecipitation, western blotting
Disease tissue studied:  lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma
Relevant cell lines - cell types - tissues:  A549 (pulmonary), L9981 (pulmonary), NL9980 (pulmonary), YTMLC-9 (pulmonary)
Cellular systems studied:  cell lines
Species studied:  bacteria, human
Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
ACETYLTRANSFERASE p300 (human) modification site within consensus motif, transfection of wild-type enzyme, siRNA inhibition of enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA decrease siRNA for p300 reduces acetylation