Curated Information
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Home > Curated Information Page > PubMed Id: 27566146
Hong X, et al. (2016) SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res 44, 8855-8869 27566146
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T236-p - SOX9 (human)
Modsite: GQSQGPPtPPtTPKT SwissProt Entrez-Gene
Orthologous residues
SOX9 (human): T236‑p, SOX9 (mouse): T236‑p, SOX9 (rat): T236‑p, SOX9 (chicken): T236‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, mutation of modification site, western blotting
Disease tissue studied:  colorectal cancer, colorectal carcinoma, lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma, non-small cell large cell lung carcinoma
Relevant cell lines - cell types - tissues:  A549 (pulmonary), HCT116 (intestinal), NCI-H1299 (pulmonary), NCI-H460 (pulmonary)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
Downstream Regulation
Effect of modification (function):  protein degradation, ubiquitination
Effect of modification (process):  apoptosis, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
FBXW7 (human) Induces apoptosis, induced co-immunoprecipitation