Curated Information
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Home > Curated Information Page > PubMed Id: 28289099
Jacobs BL, et al. (2017) Identification of mechanically regulated phosphorylation sites on tuberin (TSC2) that control mechanistic target of rapamycin (mTOR) signaling. J Biol Chem 292, 6987-6997 28289099
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S664-p - TSC2 (human)
Modsite: KkTSGPLsPPTGPPG SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): S664‑p, TSC2 iso2 (human): S664‑p, TSC2 iso3 (human): S664‑p, TSC2 iso4 (human): S664‑p, TSC2 (mouse): S664‑p, TSC2 iso6 (mouse): S664‑p, TSC2 (rat): S664‑p, TSC2 iso2 (rat): S664‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, peptide sequencing, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
eccentric contractions increase

S939-p - TSC2 (human)
Modsite: sFRARstsLNERPKs SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): S939‑p, TSC2 iso2 (human): S939‑p, TSC2 iso3 (human): S939‑p, TSC2 iso4 (human): S939‑p, TSC2 (mouse): S939‑p, TSC2 iso6 (mouse): S939‑p, TSC2 (rat): S939‑p, TSC2 iso2 (rat): S939‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, peptide sequencing, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
eccentric contractions no change compared to control

S960-p - TSC2 (human)
Modsite: PkQGLNNsPPVkEFk SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): S960‑p, TSC2 iso2 (human): , TSC2 iso3 (human): , TSC2 iso4 (human): S960‑p, TSC2 (mouse): S960‑p, TSC2 iso6 (mouse): S960‑p, TSC2 (rat): S960‑p, TSC2 iso2 (rat):
Characterization
Methods used to characterize site in vivo mass spectrometry, peptide sequencing, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse

S981-p - TSC2 (human)
Modsite: AFRCRSIsVSEHVVR SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): S981‑p, TSC2 iso2 (human): , TSC2 iso3 (human): , TSC2 iso4 (human): S981‑p, TSC2 (mouse): S981‑p, TSC2 iso6 (mouse): S981‑p, TSC2 (rat): S981‑p, TSC2 iso2 (rat):
Characterization
Methods used to characterize site in vivo mass spectrometry, peptide sequencing, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
eccentric contractions no change compared to control

S1132-p - TSC2 (human)
Modsite: RDRVRsMsGGHGLRV SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): S1132‑p, TSC2 iso2 (human): S1089‑p, TSC2 iso3 (human): S1088‑p, TSC2 iso4 (human): S1132‑p, TSC2 (mouse): S1132‑p, TSC2 iso6 (mouse): S1132‑p, TSC2 (rat): S1132‑p, TSC2 iso2 (rat): S1089‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, peptide sequencing, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
eccentric contractions no change compared to control

S1155-p - TSC2 (human)
Modsite: QFLGSATsPGPRTAP SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): S1155‑p, TSC2 iso2 (human): S1112‑p, TSC2 iso3 (human): S1111‑p, TSC2 iso4 (human): S1155‑p, TSC2 (mouse): S1155‑p, TSC2 iso6 (mouse): S1155‑p, TSC2 (rat): S1155‑p, TSC2 iso2 (rat): S1112‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, peptide sequencing, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
eccentric contractions increase

S1254-p - TSC2 (human)
Modsite: TALyksLsVPAASTA SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): S1254‑p, TSC2 iso2 (human): S1211‑p, TSC2 iso3 (human): S1210‑p, TSC2 iso4 (human): S1254‑p, TSC2 (mouse): , TSC2 iso6 (mouse): S1254‑p, TSC2 (rat): S1254‑p, TSC2 iso2 (rat): S1211‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, peptide sequencing, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
eccentric contractions increase

S1364-p - TSC2 (human)
Modsite: IPIERVVssEGGRPs SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): S1364‑p, TSC2 iso2 (human): S1321‑p, TSC2 iso3 (human): S1320‑p, TSC2 iso4 (human): S1341‑p, TSC2 (mouse): S1365‑p, TSC2 iso6 (mouse): S1343‑p, TSC2 (rat): S1366‑p, TSC2 iso2 (rat): S1323‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, peptide sequencing, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
eccentric contractions increase

S1371-p - TSC2 (human)
Modsite: ssEGGRPsVDLsFQP SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): S1371‑p, TSC2 iso2 (human): S1328‑p, TSC2 iso3 (human): S1327‑p, TSC2 iso4 (human): S1348‑p, TSC2 (mouse): A1372‑p, TSC2 iso6 (mouse): A1350‑p, TSC2 (rat): T1373‑p, TSC2 iso2 (rat): T1330‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, peptide sequencing, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse

S1411-p - TSC2 (human)
Modsite: KADVGRLsPEVKARs SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): S1411‑p, TSC2 iso2 (human): S1368‑p, TSC2 iso3 (human): S1367‑p, TSC2 iso4 (human): S1388‑p, TSC2 (mouse): S1412‑p, TSC2 iso6 (mouse): S1390‑p, TSC2 (rat): S1413‑p, TSC2 iso2 (rat): S1370‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, peptide sequencing, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse

S1420-p - TSC2 (human)
Modsite: EVKARsQsGtLDGEs SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): S1420‑p, TSC2 iso2 (human): S1377‑p, TSC2 iso3 (human): S1376‑p, TSC2 iso4 (human): S1397‑p, TSC2 (mouse): S1421‑p, TSC2 iso6 (mouse): S1399‑p, TSC2 (rat): S1422‑p, TSC2 iso2 (rat): S1379‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, peptide sequencing, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse

S1449-p - TSC2 (human)
Modsite: EGPLPSssPRsPsGL SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): S1449‑p, TSC2 iso2 (human): S1406‑p, TSC2 iso3 (human): S1405‑p, TSC2 iso4 (human): S1426‑p, TSC2 (mouse): S1452‑p, TSC2 iso6 (mouse): S1430‑p, TSC2 (rat): S1453‑p, TSC2 iso2 (rat): S1410‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, peptide sequencing, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
eccentric contractions increase

S1452-p - TSC2 (human)
Modsite: LPSssPRsPsGLRPR SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): S1452‑p, TSC2 iso2 (human): S1409‑p, TSC2 iso3 (human): S1408‑p, TSC2 iso4 (human): S1429‑p, TSC2 (mouse): S1455‑p, TSC2 iso6 (mouse): S1433‑p, TSC2 (rat): S1456‑p, TSC2 iso2 (rat): S1413‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, peptide sequencing, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
eccentric contractions increase

S1798-p - TSC2 (human)
Modsite: GQRKRLIssVEDFTE SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): S1798‑p, TSC2 iso2 (human): S1755‑p, TSC2 iso3 (human): S1754‑p, TSC2 iso4 (human): S1775‑p, TSC2 (mouse): S1805‑p, TSC2 iso6 (mouse): S1777‑p, TSC2 (rat): S1800‑p, TSC2 iso2 (rat): S1757‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, peptide sequencing, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse

S1799-p - TSC2 (human)
Modsite: QRKRLIssVEDFTEF SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): S1799‑p, TSC2 iso2 (human): S1756‑p, TSC2 iso3 (human): S1755‑p, TSC2 iso4 (human): S1776‑p, TSC2 (mouse): S1806‑p, TSC2 iso6 (mouse): S1778‑p, TSC2 (rat): S1801‑p, TSC2 iso2 (rat): S1758‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, peptide sequencing, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse

T412-p - p70S6K (mouse)
Modsite: NQVFLGFtYVAPSVL SwissProt Entrez-Gene
Orthologous residues
p70S6K (human): T412‑p, p70S6K iso2 (human): T389‑p, p70S6K (mouse): T412‑p, p70S6K (rat): T412‑p, p70S6K iso2 (rat): T389‑p, p70S6K (fruit fly): T398‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, peptide sequencing, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
eccentric contractions increase