Curated Information
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Home > Curated Information Page > PubMed Id: 28289074
Breuning J, Brown MH (2017) T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex. Mol Cell Biol 37 28289074
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y629-p - CD6 (human)
Modsite: STSSGEWyQNFQPPP SwissProt Entrez-Gene
Orthologous residues
CD6 (human): Y629‑p, CD6 (mouse): Y624‑p
Downstream Regulation
Effect of modification (function):  activity, induced, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
GADS (human) SH2 Induces pull-down assay
TSAd (human) SH2 Induces pull-down assay
GADS (human) Induces co-immunoprecipitation
GRB2 (human) SH2 Induces pull-down assay
SLP76 (human) Induces co-immunoprecipitation

Y662-p - CD6 (human)
Modsite: DSTDNDDyDDISAA_ SwissProt Entrez-Gene
Orthologous residues
CD6 (human): Y662‑p, CD6 (mouse): Y659‑p
Downstream Regulation
Effect of modification (function):  activity, induced, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
GADS (human) Induces co-immunoprecipitation
SLP76 (human) Induces co-immunoprecipitation