Thaper D, et al. (2017) Targeting Lyn regulates Snail family shuttling and inhibits metastasis. Oncogene 36, 3964-3975 28288135

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

S204-p - PAK1 (human) ▲

Modsite: tKsVyTRsVIEPLPV SwissProt Entrez-Gene Orthologous residues PAK1 (human): S204‑p, PAK1 (mouse): S204‑p, PAK1 (rat): S203‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Disease tissue studied:  breast cancer, breast cancer, triple negative, prostate cancer Relevant cell lines - cell types - tissues:  BT-549 (breast cell), LNCaP (prostate cell) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes bafetinib augment treatment-induced decrease

S247-p - Snail2 (human) ▲

Modsite: KYQCKNCsKTFsRMs SwissProt Entrez-Gene Orthologous residues Snail2 (human): S247‑p, Snail2 (mouse): S248‑p, Snail2 (rat): S247‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Disease tissue studied:  breast cancer, breast cancer, triple negative, prostate cancer Relevant cell lines - cell types - tissues:  BT-549 (breast cell), LNCaP (prostate cell) Cellular systems studied:  cell lines Species studied:  human

S251-p - Snail2 (human) ▲

Modsite: KNCsKTFsRMsLLHK SwissProt Entrez-Gene Orthologous residues Snail2 (human): S251‑p, Snail2 (mouse): S252‑p, Snail2 (rat): S251‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Disease tissue studied:  breast cancer, breast cancer, triple negative, prostate cancer Relevant cell lines - cell types - tissues:  BT-549 (breast cell), LNCaP (prostate cell) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PAK1 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PAK1 (human) modification site within consensus motif, co-immunoprecipitation Downstream Regulation Effect of modification (function):  intracellular localization Effect of modification (process):  transcription, induced Comments:  nuclear localization

S254-p - Snail2 (human) ▲

Modsite: sKTFsRMsLLHKHEE SwissProt Entrez-Gene Orthologous residues Snail2 (human): S254‑p, Snail2 (mouse): S255‑p, Snail2 (rat): S254‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Disease tissue studied:  breast cancer, breast cancer, triple negative, prostate cancer Relevant cell lines - cell types - tissues:  BT-549 (breast cell), LNCaP (prostate cell) Cellular systems studied:  cell lines Species studied:  human

Y174-p - VAV1 (human) ▲

Modsite: EAEGDEIyEDLMRsE SwissProt Entrez-Gene Orthologous residues VAV1 (human): Y174‑p, VAV1 iso2 (human): Y174‑p, VAV1 (mouse): Y174‑p, VAV1 (rat): Y174‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Disease tissue studied:  breast cancer, breast cancer, triple negative, prostate cancer Relevant cell lines - cell types - tissues:  BT-549 (breast cell), LNCaP (prostate cell) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes bafetinib augment treatment-induced decrease