Gatla HR, et al. (2017) Histone Deacetylase (HDAC) Inhibition Induces IκB Kinase (IKK)-dependent Interleukin-8/CXCL8 Expression in Ovarian Cancer Cells. J Biol Chem 292, 5043-5054 28167529

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

K9-ac - H3 (human) ▲

Modsite: rtkQtArkstGGkAP SwissProt Entrez-Gene Orthologous residues H3 (human): K9‑ac, H3 (mouse): K9‑ac, H3 iso2 (mouse): K9‑ac, H3 iso3 (mouse): K9‑ac, H3 (rat): K9‑ac, H3 iso3 (rat): K9‑ac, H3 (pig): K9‑ac, H3 (chicken): K9‑ac, H3 (cow): K9‑ac Characterization Methods used to characterize site in vivo:  modification-specific antibody, western blotting Disease tissue studied:  ovarian cancer Relevant cell lines - cell types - tissues:  SKOV-3 (ovarian) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes vorinostat increase Downstream Regulation Effect of modification (process):  carcinogenesis, induced, cell growth, induced, transcription, induced

K14-ac - H3 (human) ▲

Modsite: ArkstGGkAPrkQLA SwissProt Entrez-Gene Orthologous residues H3 (human): K14‑ac, H3 (mouse): K14‑ac, H3 iso2 (mouse): K14‑ac, H3 iso3 (mouse): K14‑ac, H3 (rat): K14‑ac, H3 iso3 (rat): K14‑ac, H3 (pig): K14‑ac, H3 (chicken): K14‑ac, H3 (cow): K14‑ac Characterization Methods used to characterize site in vivo:  modification-specific antibody, western blotting Disease tissue studied:  ovarian cancer Relevant cell lines - cell types - tissues:  SKOV-3 (ovarian) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes vorinostat increase Downstream Regulation Effect of modification (process):  carcinogenesis, induced, cell growth, induced, transcription, induced

K314-ac - NFkB-p65 (human) ▲

Modsite: EtFksIMkksPFsGP SwissProt Entrez-Gene Orthologous residues NFkB‑p65 (human): K314‑ac, NFkB‑p65 (mouse): K314‑ac, NFkB‑p65 (rat): K314‑ac Characterization Methods used to characterize site in vivo:  modification-specific antibody, western blotting Disease tissue studied:  ovarian cancer Relevant cell lines - cell types - tissues:  SKOV-3 (ovarian) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes vorinostat increase Downstream Regulation Effect of modification (process):  carcinogenesis, induced, cell growth, induced, transcription, induced

K315-ac - NFkB-p65 (human) ▲

Modsite: tFksIMkksPFsGPt SwissProt Entrez-Gene Orthologous residues NFkB‑p65 (human): K315‑ac, NFkB‑p65 (mouse): K315‑ac, NFkB‑p65 (rat): K315‑ac Characterization Methods used to characterize site in vivo:  modification-specific antibody, western blotting Disease tissue studied:  ovarian cancer Relevant cell lines - cell types - tissues:  SKOV-3 (ovarian) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes vorinostat increase Downstream Regulation Effect of modification (process):  carcinogenesis, induced, cell growth, induced, transcription, induced