Curated Information
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Home > Curated Information Page > PubMed Id: 28237688
Misuth M, et al. (2017) The flashlights on a distinct role of protein kinase C δ: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells. Cell Signal 34, 11-22 28237688
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S70-p - Bcl-2 (human)
Modsite: RDPVARtsPLQtPAA SwissProt Entrez-Gene
Orthologous residues
Bcl‑2 (human): S70‑p, Bcl‑2 (mouse): S70‑p, Bcl‑2 (rat): S70‑p
Characterization
Methods used to characterize site in vivo immunoassay, phospho-antibody, western blotting
Disease tissue studied:  brain cancer, glioblastoma, glioma
Relevant cell lines - cell types - tissues:  U87MG (glial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCD (human) microscopy-colocalization
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Hypericin increase
light, Hypericin increase increase followed by decrease
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  apoptosis, induced
Comments:  decreased in the cytoplasm and increased in the nucleus

Y155-p - PKCD (human)
Modsite: IKQAKIHyIKNHEFI SwissProt Entrez-Gene
Orthologous residues
PKCD (human): Y155‑p, PKCD iso2 (human): Y155‑p, PKCD (mouse): Y155‑p, PKCD iso2 (mouse): Y155‑p, PKCD (rat): Y155‑p
Characterization
Methods used to characterize site in vivo immunoassay, phospho-antibody, western blotting
Disease tissue studied:  brain cancer, glioblastoma, glioma
Relevant cell lines - cell types - tissues:  U87MG (glial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Hypericin increase
light, Hypericin increase increase followed by decrease
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  apoptosis, induced
Comments:  localized in mitochondria, perinuclear and nuclear at 5 hr after irradiation

S645-p - PKCD (human)
Modsite: LNEkARLsysDKNLI SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S645‑p, PKCD iso2 (human): S676‑p, PKCD (mouse): S643‑p, PKCD iso2 (mouse): S669‑p, PKCD (rat): S643‑p
Characterization
Methods used to characterize site in vivo immunoassay, phospho-antibody, western blotting
Disease tissue studied:  brain cancer, glioblastoma, glioma
Relevant cell lines - cell types - tissues:  U87MG (glial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Hypericin increase
light, Hypericin increase
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  localized in the nucleus and the Golgi apparatus/ER area