Kremer JC, et al. (2017) Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers. Cell Rep 18, 991-1004 28122247

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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Y10-p - LDH-A (human) ▲

Modsite: tLkDQLIyNLLkEEQ SwissProt Entrez-Gene Orthologous residues LDH‑A (human): Y10‑p, LDH‑A iso2 (human): Y10‑p, LDH‑A iso3 (human): Y39‑p, LDH‑A (mouse): V10‑p, LDH‑A (rat): V10‑p, LDH‑A (chicken): H9‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  melanoma skin cancer, leiomyosarcoma Relevant cell lines - cell types - tissues:  SK-LMS-1 (muscle cell), SK-MEL2 (melanocyte), SKUT-1 Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ADI-PEG20 decrease Downstream Regulation Effect of modification (function):  enzymatic activity, induced

S300-p - PDHA1 (human) ▲

Modsite: sMsDPGVsyRtREEI SwissProt Entrez-Gene Orthologous residues PDHA1 (human): S300‑p, PDHA1 iso2 (human): S307‑p, PDHA1 iso4 (human): S338‑p, PDHA1 (mouse): S300‑p, PDHA1 (rat): S300‑p, PDHA1 (pig): S299‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  melanoma skin cancer, leiomyosarcoma Relevant cell lines - cell types - tissues:  SK-LMS-1 (muscle cell), SK-MEL2 (melanocyte), SKUT-1 Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ADI-PEG20 increase Downstream Regulation Effect of modification (function):  enzymatic activity, inhibited