Curated Information
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Home > Curated Information Page > PubMed Id: 28039298
Zhu G, et al. (2017) Sublytic C5b-9 Induces Glomerular Mesangial Cell Apoptosis through the Cascade Pathway of MEKK2-p38 MAPK-IRF-1-TRADD-Caspase 8 in Rat Thy-1 Nephritis. J Immunol 198, 1104-1118 28039298
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S153-p - MEKK2 (rat)
Modsite: AERKKRLsVVGPPNR SwissProt Entrez-Gene
Orthologous residues
MEKK2 (human): S153‑p, MEKK2 (mouse): S153‑p, MEKK2 (rat): S153‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
C5b-9 increase

S164-p - MEKK2 (rat)
Modsite: PPNRDRssPPPGYIP SwissProt Entrez-Gene
Orthologous residues
MEKK2 (human): S164‑p, MEKK2 (mouse): S164‑p, MEKK2 (rat): S164‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
C5b-9 increase

S239-p - MEKK2 (rat)
Modsite: SRMPRAQsYPDNHQE SwissProt Entrez-Gene
Orthologous residues
MEKK2 (human): S239‑p, MEKK2 (mouse): S239‑p, MEKK2 (rat): S239‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
C5b-9 increase

T180-p - P38A (rat)
Modsite: RHTDDEMtGyVATRW SwissProt Entrez-Gene
Orthologous residues
P38A (human): T180‑p, P38A iso2 (human): T180‑p, P38A (mouse): T180‑p, P38A iso3 (mouse): T180‑p, P38A (rat): T180‑p, P38A (salmonid): T181‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
C5b-9 increase

Y182-p - P38A (rat)
Modsite: TDDEMtGyVATRWYR SwissProt Entrez-Gene
Orthologous residues
P38A (human): Y182‑p, P38A iso2 (human): Y182‑p, P38A (mouse): Y182‑p, P38A iso3 (mouse): Y182‑p, P38A (rat): Y182‑p, P38A (salmonid): Y183‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
C5b-9 increase