Curated Information
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Home > Curated Information Page > PubMed Id: 28035057
Mazar J, et al. (2017) The long non-coding RNA GAS5 differentially regulates cell cycle arrest and apoptosis through activation of BRCA1 and p53 in human neuroblastoma. Oncotarget 8, 6589-6607 28035057
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S1457-p - BRCA1 (human)
Modsite: SEKAVLTsQKsSEYP SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S1457‑p, BRCA1 iso6 (human): S353‑p, BRCA1 iso7 (human): S1478‑p, BRCA1 (mouse): S1413‑p, BRCA1 (rat): S1414‑p
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  IMR32 (neural crest)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lncRNAs decrease long non-coding RNA GAS5 siRNA increase
lncRNAs BRCA1 (human) increase BRCA1 siRNA decrease
lncRNAs GADD45A (human) decrease GADD45A siRNA increase